Use of Allogeneic Hematopoietic Stem-Cell Transplantation Based on Minimal Residual Disease Response Improves Outcomes for Children With Relapsed Acute Lymphoblastic Leukemia in the Intermediate-Risk Group

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209569" target="_blank" >RIV/00064203:_____/13:10209569 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10209569

Výsledek na webu

<a href="http://dx.doi.org/10.1200/JCO.2012.48.5680" target="_blank" >http://dx.doi.org/10.1200/JCO.2012.48.5680</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1200/JCO.2012.48.5680" target="_blank" >10.1200/JCO.2012.48.5680</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Use of Allogeneic Hematopoietic Stem-Cell Transplantation Based on Minimal Residual Disease Response Improves Outcomes for Children With Relapsed Acute Lymphoblastic Leukemia in the Intermediate-Risk Group

Popis výsledku v původním jazyce

Purpose In children with intermediate risk of relapse of acute lymphoblastic leukemia (ALL), it is essential to identify patients in need of treatment intensification. We hypothesized that the prognosis of patients with unsatisfactory reduction of minimal residual disease (MRD) can be improved by allogeneic hematopoietic stem-cell transplantation (HSCT). Patients and Methods In the Acute Lymphoblastic Leukemia-Relapse Study of the Berlin-Frankfurt-Munster Group (ALL-REZ BFM) 2002, patients with an MRD level of }= 10(-3) (n = 99) at the end of induction therapy were allocated to HSCT, whereas those with an MRD level less than 10(-3) (n = 109) continued to receive chemotherapy. MRD was quantified by real-time polymerase chain reaction for clone-specificT-cell receptor/immunoglobulin gene rearrangements. Results The probability of event-free survival for patients with MRD }= 10(-3) was 64% +/- 5% in ALL-REZ BFM 2002 compared with 18% +/- 7% in the predecessor study ALL-REZ BFM P95/96 (P

Název v anglickém jazyce

Use of Allogeneic Hematopoietic Stem-Cell Transplantation Based on Minimal Residual Disease Response Improves Outcomes for Children With Relapsed Acute Lymphoblastic Leukemia in the Intermediate-Risk Group

Popis výsledku anglicky

Purpose In children with intermediate risk of relapse of acute lymphoblastic leukemia (ALL), it is essential to identify patients in need of treatment intensification. We hypothesized that the prognosis of patients with unsatisfactory reduction of minimal residual disease (MRD) can be improved by allogeneic hematopoietic stem-cell transplantation (HSCT). Patients and Methods In the Acute Lymphoblastic Leukemia-Relapse Study of the Berlin-Frankfurt-Munster Group (ALL-REZ BFM) 2002, patients with an MRD level of }= 10(-3) (n = 99) at the end of induction therapy were allocated to HSCT, whereas those with an MRD level less than 10(-3) (n = 109) continued to receive chemotherapy. MRD was quantified by real-time polymerase chain reaction for clone-specificT-cell receptor/immunoglobulin gene rearrangements. Results The probability of event-free survival for patients with MRD }= 10(-3) was 64% +/- 5% in ALL-REZ BFM 2002 compared with 18% +/- 7% in the predecessor study ALL-REZ BFM P95/96 (P

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Oncology

ISSN

0732-183X

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

2736-2742

Kód UT WoS článku

000330538700023

EID výsledku v databázi Scopus

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