Impact of histological variants ononcological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209659" target="_blank" >RIV/00064203:_____/13:10209659 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10209659

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejca.2013.02.001" target="_blank" >http://dx.doi.org/10.1016/j.ejca.2013.02.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejca.2013.02.001" target="_blank" >10.1016/j.ejca.2013.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of histological variants ononcological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

Popis výsledku v původním jazyce

Objective: To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC). Materials and Methods: Data from 1984 UCB patients treated by RC without preoperative chemo-or radiotherapy were reviewed for histological differentiation and variants. We analysed the differences between pure UCB and UCB with variant histology, and those between the different histological variants using various stratifications. Results: Overall, 488 (24.6%) patients had UCB variants with squamous cell (11.4%) and glandular differentiation (3.8%) being the most common. Histological UCB variants were associated with advanced tumour stage, lymphovascular invasion and lymph node metastasis (all p-values <0.01) when compared to pure UCB. In univariable analyses, patients with non-squamous UCB variants were at significantly higher risk for disease recurrence and cancer-specific mortality than those with pure UCB patients (p-values = 0.

Název v anglickém jazyce

Impact of histological variants ononcological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

Popis výsledku anglicky

Objective: To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC). Materials and Methods: Data from 1984 UCB patients treated by RC without preoperative chemo-or radiotherapy were reviewed for histological differentiation and variants. We analysed the differences between pure UCB and UCB with variant histology, and those between the different histological variants using various stratifications. Results: Overall, 488 (24.6%) patients had UCB variants with squamous cell (11.4%) and glandular differentiation (3.8%) being the most common. Histological UCB variants were associated with advanced tumour stage, lymphovascular invasion and lymph node metastasis (all p-values <0.01) when compared to pure UCB. In univariable analyses, patients with non-squamous UCB variants were at significantly higher risk for disease recurrence and cancer-specific mortality than those with pure UCB patients (p-values = 0.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Cancer

ISSN

0959-8049

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1889-1897

Kód UT WoS článku

000318610500011

EID výsledku v databázi Scopus

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