p16(INK4a) Immunoprofiles of Squamous Lesions of the Uterine Cervix-Implications for the Reclassification of Atypical Immature Squamous Metaplasia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209713" target="_blank" >RIV/00064203:_____/13:10209713 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10209713

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s12253-013-9633-1" target="_blank" >http://dx.doi.org/10.1007/s12253-013-9633-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12253-013-9633-1" target="_blank" >10.1007/s12253-013-9633-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

p16(INK4a) Immunoprofiles of Squamous Lesions of the Uterine Cervix-Implications for the Reclassification of Atypical Immature Squamous Metaplasia

Popis výsledku v původním jazyce

p16(INK4a) immunoprofiles of non-precancerous and dysplastic squamous cervical lesions were defined and applied to the reclassification of atypical immature squamous metaplasia (AIM). The immunoexpression of cytokeratin 17 (CK 17) in AIM was also evaluated. Totally, 295 cervical cone biopsies representing squamous metaplasia, reactive changes, koilocytosis, flat condyloma, CIN I, CIN II, CIN III and AIM were subjected to p16(INK4a) immunohistochemistry. AIM cases were analyzed using CK 17 antibody. Typical p16(INK4a) immunoprofiles for the metaplastic, LSIL/HPV and HSIL phenotypes were recorded and used for the categorization of AIM into particular phenotype groups. Results were correlated with CK 17 immunoexpression. All CIN II and CIN III lesions, all but one case of CIN I and all flat condylomas overexpressed p16(INK4a). Other non-precancerous lesions, including koilocytosis, were predominantly negative. Contrary to the sporadic and focal immunostaining, diffuse positivity was assoc

Název v anglickém jazyce

p16(INK4a) Immunoprofiles of Squamous Lesions of the Uterine Cervix-Implications for the Reclassification of Atypical Immature Squamous Metaplasia

Popis výsledku anglicky

p16(INK4a) immunoprofiles of non-precancerous and dysplastic squamous cervical lesions were defined and applied to the reclassification of atypical immature squamous metaplasia (AIM). The immunoexpression of cytokeratin 17 (CK 17) in AIM was also evaluated. Totally, 295 cervical cone biopsies representing squamous metaplasia, reactive changes, koilocytosis, flat condyloma, CIN I, CIN II, CIN III and AIM were subjected to p16(INK4a) immunohistochemistry. AIM cases were analyzed using CK 17 antibody. Typical p16(INK4a) immunoprofiles for the metaplastic, LSIL/HPV and HSIL phenotypes were recorded and used for the categorization of AIM into particular phenotype groups. Results were correlated with CK 17 immunoexpression. All CIN II and CIN III lesions, all but one case of CIN I and all flat condylomas overexpressed p16(INK4a). Other non-precancerous lesions, including koilocytosis, were predominantly negative. Contrary to the sporadic and focal immunostaining, diffuse positivity was assoc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathology Oncology Research

ISSN

1219-4956

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

HU - Maďarsko

Počet stran výsledku

8

Strana od-do

707-714

Kód UT WoS článku

000324638600012

EID výsledku v databázi Scopus

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