Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209750" target="_blank" >RIV/00064203:_____/13:10209750 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10209750

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.imlet.2013.05.010" target="_blank" >http://dx.doi.org/10.1016/j.imlet.2013.05.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.imlet.2013.05.010" target="_blank" >10.1016/j.imlet.2013.05.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma

Popis výsledku v původním jazyce

We evaluated dendritic cells (DC), regulatory T lymphocytes (Treg) and neutrophils in 37 patients with newly diagnosed renal cell carcinoma (RCC) in the tumor and peripheral blood (PB) and correlated these parameters with tumor staging (early-T1, 2, late-T3, 4 and metastatic disease). The number of myeloid and plasmacytoid DC in blood of RCC patients was higher than in healthy controls. The percentage of myeloid dendritic cells (mDC) from CD45+ cells in tumors was higher in comparison with peripheral blood irrespective of disease stage. Higher percentage of these cells expressed a maturation marker in the periphery in the early stage (CD83 expressing cells). The number of plasmacytoid dendritic cells (pDC) in PB was similar in both early and late stagegroups, but the early group displayed a significantly higher percentage of pDC in tumor cell suspension. Neutrophil counts in the peripheral blood of RCC patients were higher than in healthy controls, but the counts in-both tumor stage g

Název v anglickém jazyce

Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma

Popis výsledku anglicky

We evaluated dendritic cells (DC), regulatory T lymphocytes (Treg) and neutrophils in 37 patients with newly diagnosed renal cell carcinoma (RCC) in the tumor and peripheral blood (PB) and correlated these parameters with tumor staging (early-T1, 2, late-T3, 4 and metastatic disease). The number of myeloid and plasmacytoid DC in blood of RCC patients was higher than in healthy controls. The percentage of myeloid dendritic cells (mDC) from CD45+ cells in tumors was higher in comparison with peripheral blood irrespective of disease stage. Higher percentage of these cells expressed a maturation marker in the periphery in the early stage (CD83 expressing cells). The number of plasmacytoid dendritic cells (pDC) in PB was similar in both early and late stagegroups, but the early group displayed a significantly higher percentage of pDC in tumor cell suspension. Neutrophil counts in the peripheral blood of RCC patients were higher than in healthy controls, but the counts in-both tumor stage g

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11559" target="_blank" >NT11559: Fáze I/II klinické studie imunoterapie karcinomu prostaty pomocí vakcinace dendritickými buňkami</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunology Letters

ISSN

0165-2478

e-ISSN

—

Svazek periodika

152

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

144-150

Kód UT WoS článku

000322294100010

EID výsledku v databázi Scopus

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