Disease Activity Is an Important Factor for Indeterminate Interferon-gamma Release Assay Results in Children With Inflammatory Bowel Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292791" target="_blank" >RIV/00064203:_____/14:10292791 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/14:10292791 RIV/75010330:_____/14:00010730

Výsledek na webu

<a href="http://dx.doi.org/10.1097/MPG.0000000000000205" target="_blank" >http://dx.doi.org/10.1097/MPG.0000000000000205</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MPG.0000000000000205" target="_blank" >10.1097/MPG.0000000000000205</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Disease Activity Is an Important Factor for Indeterminate Interferon-gamma Release Assay Results in Children With Inflammatory Bowel Disease

Popis výsledku v původním jazyce

Background:Interferon- release assay (IGRA) is widely used for screening of latent tuberculosis (TB) before and during biological therapy (BT). An indeterminate result of IGRA represents a limitation in the management of inflammatory bowel disease (IBD).Data on factors influencing IGRA results are scarce in children. The aim of the study was to identify factors influencing IGRA results in children with IBD.Methods:Seventy-two children with IBD (59 Crohn disease, 11 ulcerative colitis, 2 IBD-unclassified) indicated for BT were tested for TB infection (history, TB skin test, chest radiograph, IGRA; QuantiFERONTB Gold in tube [QFT]) and consecutively retested using QFT in 1-year intervals.Results:We recorded 165 results of QFT (3% positive, 87% negative,and 10% indeterminate results). During follow-up we identified 4 conversions of negative QFT to positivity (3%) and 4 reversions (4%). Patients with indeterminate results of QFT had significantly lower actual weight-for-height z score (P

Název v anglickém jazyce

Disease Activity Is an Important Factor for Indeterminate Interferon-gamma Release Assay Results in Children With Inflammatory Bowel Disease

Popis výsledku anglicky

Background:Interferon- release assay (IGRA) is widely used for screening of latent tuberculosis (TB) before and during biological therapy (BT). An indeterminate result of IGRA represents a limitation in the management of inflammatory bowel disease (IBD).Data on factors influencing IGRA results are scarce in children. The aim of the study was to identify factors influencing IGRA results in children with IBD.Methods:Seventy-two children with IBD (59 Crohn disease, 11 ulcerative colitis, 2 IBD-unclassified) indicated for BT were tested for TB infection (history, TB skin test, chest radiograph, IGRA; QuantiFERONTB Gold in tube [QFT]) and consecutively retested using QFT in 1-year intervals.Results:We recorded 165 results of QFT (3% positive, 87% negative,and 10% indeterminate results). During follow-up we identified 4 conversions of negative QFT to positivity (3%) and 4 reversions (4%). Patients with indeterminate results of QFT had significantly lower actual weight-for-height z score (P

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pediatric Gastroenterology and Nutrition

ISSN

0277-2116

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

320-324

Kód UT WoS článku

000333297300014

EID výsledku v databázi Scopus

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