DNA methylation-associated colonic mucosal immune and defense responses in treatment-naive pediatric ulcerative colitis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292957" target="_blank" >RIV/00064203:_____/14:10292957 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/14:10292957
Výsledek na webu
<a href="http://dx.doi.org/10.4161/epi.29446" target="_blank" >http://dx.doi.org/10.4161/epi.29446</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/epi.29446" target="_blank" >10.4161/epi.29446</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naive pediatric ulcerative colitis
Popis výsledku v původním jazyce
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been implicated in IBD pathology. However, mucosal DNA methylation has not been examined in treatment-naive patients. We studied DNA methylation in untreated, left sided colonic biopsy specimens using the Infinium HumanMethylation450 BeadChip array. We analyzed22 control (C) patients, 15 untreated Crohn's disease (CD) patients, and 9 untreated ulcerative colitis (UC) patients from two cohorts. Samples obtained at the time of clinical remission from two of the treatment-naive UC patients were also included intothe analysis. UC-specific gene expression was interrogated in a subset of adjacent samples (5 C and 5 UC) using the Affymetrix GeneChip PrimeView Human Gene Expression Arrays. Only treatment-naive UC separated from control. One-hundred-a
Název v anglickém jazyce
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naive pediatric ulcerative colitis
Popis výsledku anglicky
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been implicated in IBD pathology. However, mucosal DNA methylation has not been examined in treatment-naive patients. We studied DNA methylation in untreated, left sided colonic biopsy specimens using the Infinium HumanMethylation450 BeadChip array. We analyzed22 control (C) patients, 15 untreated Crohn's disease (CD) patients, and 9 untreated ulcerative colitis (UC) patients from two cohorts. Samples obtained at the time of clinical remission from two of the treatment-naive UC patients were also included intothe analysis. UC-specific gene expression was interrogated in a subset of adjacent samples (5 C and 5 UC) using the Affymetrix GeneChip PrimeView Human Gene Expression Arrays. Only treatment-naive UC separated from control. One-hundred-a
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Epigenetics
ISSN
1559-2294
e-ISSN
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Svazek periodika
9
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
1131-1137
Kód UT WoS článku
000341360600008
EID výsledku v databázi Scopus
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