Helios Expression in T-regulatory Cells in Patients with di George Syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292990" target="_blank" >RIV/00064203:_____/14:10292990 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/14:10292990

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10875-014-0071-y" target="_blank" >http://dx.doi.org/10.1007/s10875-014-0071-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10875-014-0071-y" target="_blank" >10.1007/s10875-014-0071-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Helios Expression in T-regulatory Cells in Patients with di George Syndrome

Popis výsledku v původním jazyce

Syndrome diGeorge is associated amongst other clinical signs with various degrees of thymic dysplasia, related immunodeficiency and autoimmune disorders. Helios, a transcription factor from Ikaros family, has been proposed as a marker for thymus derivedTregs. We therefore examined Helios + Tregs in a cohort of patients with genetically proven diGeorge syndrome with typical T cell lymphopenia due to the thymic pathology. T cells, FoxP3+ Tregs and Helios + FoxP3+ Tregs were examined in 52 samples from 37patients. One patient with diGeorge/CHARGE syndrome with total thymic aplasia was also included. Statistical analysis was performed using a linear regression comparison. Total absolute Tregs were significantly lower in diGeorge patients as compared to controls in all age groups (0-20 years) (p = 0.0016). The difference was more expressed in the first four years of age. Relative Treg numbers expressed as the percentage of Tregs in CD4+ T-cells, however, were not different in patients and

Název v anglickém jazyce

Helios Expression in T-regulatory Cells in Patients with di George Syndrome

Popis výsledku anglicky

Syndrome diGeorge is associated amongst other clinical signs with various degrees of thymic dysplasia, related immunodeficiency and autoimmune disorders. Helios, a transcription factor from Ikaros family, has been proposed as a marker for thymus derivedTregs. We therefore examined Helios + Tregs in a cohort of patients with genetically proven diGeorge syndrome with typical T cell lymphopenia due to the thymic pathology. T cells, FoxP3+ Tregs and Helios + FoxP3+ Tregs were examined in 52 samples from 37patients. One patient with diGeorge/CHARGE syndrome with total thymic aplasia was also included. Statistical analysis was performed using a linear regression comparison. Total absolute Tregs were significantly lower in diGeorge patients as compared to controls in all age groups (0-20 years) (p = 0.0016). The difference was more expressed in the first four years of age. Relative Treg numbers expressed as the percentage of Tregs in CD4+ T-cells, however, were not different in patients and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13287" target="_blank" >NT13287: Regulace imunity u syndromu DiGeorge.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Immunology

ISSN

0271-9142

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

864-870

Kód UT WoS článku

000342212000016

EID výsledku v databázi Scopus

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