Post-mortem analysis of Candida albicans breakthrough infection during echinocandin treatment in haematopoietic stem cell transplant recipient
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293096" target="_blank" >RIV/00064203:_____/14:10293096 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/14:10293096
Výsledek na webu
<a href="http://www.prolekare.cz/en/epidemiology-article/post-mortem-analysis-of-candida-albicans-breakthrough-infection-during-echinocandin-treatment-in-haematopoietic-stem-49183" target="_blank" >http://www.prolekare.cz/en/epidemiology-article/post-mortem-analysis-of-candida-albicans-breakthrough-infection-during-echinocandin-treatment-in-haematopoietic-stem-49183</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Post-mortem analysis of Candida albicans breakthrough infection during echinocandin treatment in haematopoietic stem cell transplant recipient
Popis výsledku v původním jazyce
We present case of a girl deceased due to Candida albicans breakthrough invasive infection during the echinocandin treatment after undergoing allogeneic haematopoietic stem cell transplant for relaps of acute myeloid leukaemia. Candida albicans generallysusceptible to all antifungal drugs wasn't considered for potential resistance and conventional blood culture positivity was too late to reveal the resistance to echinocandins. Due to severe organ toxicities (liver, kidneys) she received echinocandin asan antifungal prophylaxis, no change was made for the treatment of Candida albicans infection. Later, the molecular analysis proved the mutation S645P known as being responsible for the echinocandin resistance. The post mortem analysis of fungal burdenin autopsy samples showed very high levels of Candida DNA in gut, liver, spleen and kidneys.
Název v anglickém jazyce
Post-mortem analysis of Candida albicans breakthrough infection during echinocandin treatment in haematopoietic stem cell transplant recipient
Popis výsledku anglicky
We present case of a girl deceased due to Candida albicans breakthrough invasive infection during the echinocandin treatment after undergoing allogeneic haematopoietic stem cell transplant for relaps of acute myeloid leukaemia. Candida albicans generallysusceptible to all antifungal drugs wasn't considered for potential resistance and conventional blood culture positivity was too late to reveal the resistance to echinocandins. Due to severe organ toxicities (liver, kidneys) she received echinocandin asan antifungal prophylaxis, no change was made for the treatment of Candida albicans infection. Later, the molecular analysis proved the mutation S645P known as being responsible for the echinocandin resistance. The post mortem analysis of fungal burdenin autopsy samples showed very high levels of Candida DNA in gut, liver, spleen and kidneys.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EE - Mikrobiologie, virologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Epidemiologie, Mikrobiologie, Imunologie
ISSN
1210-7913
e-ISSN
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Svazek periodika
63
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
4
Strana od-do
121-124
Kód UT WoS článku
000343635300010
EID výsledku v databázi Scopus
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