Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10323713" target="_blank" >RIV/00064203:_____/16:10323713 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10323713

Výsledek na webu

<a href="http://dx.doi.org/10.1002/pbc.25855" target="_blank" >http://dx.doi.org/10.1002/pbc.25855</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pbc.25855" target="_blank" >10.1002/pbc.25855</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis

Popis výsledku v původním jazyce

BackgroundThe risk of early death (ED) by bleeding/leukostasis is high in patients with AML with hyperleukocytosis (>100,000/l). Within the pediatric AML-BFM (Berlin-Frankfurt-Munster) 98/04 studies, emergency strategies for these children included exchange transfusion (ET) or leukapheresis (LPh). Risk factors for ED and interventions performed were analyzed. PatientsTwo hundred thirty-eight of 1,251 (19%) patients with AML presented with hyperleukocytosis; 23 of 1,251 (1.8%) patients died of bleeding/leukostasis. ResultsED due to bleeding/leukostasis was highest at white blood cell (WBC) count >200,000/l (14.3%). ED rates were even higher (20%) in patients with FAB (French-American-British) M4/M5 and hyperleukocytosis >200,000/l. Patients with WBC >200,000/l did slightly better with ET/LPh compared to those without ET/LPh (ED rate 7.5% vs. 21.2%, P = 0.055). Multivariate WBC >200,000/l was of strongest prognostic significance for ED (P((2)) <0.0001). ConclusionOur data confirm the high risk of bleeding/leukostasis in patients with hyperleukocytosis. ET/LPh shows a trend toward reduced ED rate due to bleeding/leukostasis and is recommended at WBC >200,000/l, and in FAB M4/M5 even at lower WBC.

Název v anglickém jazyce

Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis

Popis výsledku anglicky

BackgroundThe risk of early death (ED) by bleeding/leukostasis is high in patients with AML with hyperleukocytosis (>100,000/l). Within the pediatric AML-BFM (Berlin-Frankfurt-Munster) 98/04 studies, emergency strategies for these children included exchange transfusion (ET) or leukapheresis (LPh). Risk factors for ED and interventions performed were analyzed. PatientsTwo hundred thirty-eight of 1,251 (19%) patients with AML presented with hyperleukocytosis; 23 of 1,251 (1.8%) patients died of bleeding/leukostasis. ResultsED due to bleeding/leukostasis was highest at white blood cell (WBC) count >200,000/l (14.3%). ED rates were even higher (20%) in patients with FAB (French-American-British) M4/M5 and hyperleukocytosis >200,000/l. Patients with WBC >200,000/l did slightly better with ET/LPh compared to those without ET/LPh (ED rate 7.5% vs. 21.2%, P = 0.055). Multivariate WBC >200,000/l was of strongest prognostic significance for ED (P((2)) <0.0001). ConclusionOur data confirm the high risk of bleeding/leukostasis in patients with hyperleukocytosis. ET/LPh shows a trend toward reduced ED rate due to bleeding/leukostasis and is recommended at WBC >200,000/l, and in FAB M4/M5 even at lower WBC.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatric Blood and Cancer

ISSN

1545-5009

e-ISSN

—

Svazek periodika

63

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

640-645

Kód UT WoS článku

000370497100012

EID výsledku v databázi Scopus

2-s2.0-84959512935