Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F17%3A10365788" target="_blank" >RIV/00064203:_____/17:10365788 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/17:43919194 RIV/00216208:11110/17:10365788 RIV/00216208:11120/17:43915609 RIV/00216208:11130/17:10365788 RIV/00064173:_____/17:N0000171

Výsledek na webu

<a href="http://biomed.papers.upol.cz/pdfs/bio/2017/03/08.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2017/03/08.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2017.038" target="_blank" >10.5507/bp.2017.038</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Popis výsledku v původním jazyce

Aims: The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins between neurodegeneration and neuroinflammation. Methods: CSF and serum levels of neurofilament light subunits (NFL) and neurofilament heavy subunits (NFH) as well as CSF levels of total tau (t-tau) and phosphorylated tau (p-tau) proteins were determined using ELISA in 20 Alzheimer&apos;s disease patients (AD group), 13 patients with other dementias (OD group), 17 patients with inflammatory aseptic neuro-infections (IP), and 20 aged-matched cognitively normal elderly persons (NC group). Results: The ratio CSF p-tau/t-tau was significantly higher in the NC group than that in the AD or OD groups (P&lt;0.0005 for each group). The CSF NFH/p-tau and CSF NFL/p-tau ratios were significantly lower in AD patients than OD patients (P&lt;=0.003). Serum and CSF NFL and CSF NFH levels were significantly higher in OD patients than AD patients (P&lt;=0.03). The lowest values of the CSF NFL/NFH ratio were found in the IP group and they significantly differed from those in normal controls (P&lt;0.0001) and any dementia group (IP vs. AD P&lt;0.0001; IP vs. OD P=0.03). Conclusion: CSF tau proteins and their index differentiated between AD or OD patients and cognitively normal subjects, while CSF levels of neurofilaments expressed as their index seem to contribute to the discrimination between patients with neuroinflammation and normal controls or AD patients.

Název v anglickém jazyce

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Popis výsledku anglicky

Aims: The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins between neurodegeneration and neuroinflammation. Methods: CSF and serum levels of neurofilament light subunits (NFL) and neurofilament heavy subunits (NFH) as well as CSF levels of total tau (t-tau) and phosphorylated tau (p-tau) proteins were determined using ELISA in 20 Alzheimer&apos;s disease patients (AD group), 13 patients with other dementias (OD group), 17 patients with inflammatory aseptic neuro-infections (IP), and 20 aged-matched cognitively normal elderly persons (NC group). Results: The ratio CSF p-tau/t-tau was significantly higher in the NC group than that in the AD or OD groups (P&lt;0.0005 for each group). The CSF NFH/p-tau and CSF NFL/p-tau ratios were significantly lower in AD patients than OD patients (P&lt;=0.003). Serum and CSF NFL and CSF NFH levels were significantly higher in OD patients than AD patients (P&lt;=0.03). The lowest values of the CSF NFL/NFH ratio were found in the IP group and they significantly differed from those in normal controls (P&lt;0.0001) and any dementia group (IP vs. AD P&lt;0.0001; IP vs. OD P=0.03). Conclusion: CSF tau proteins and their index differentiated between AD or OD patients and cognitively normal subjects, while CSF levels of neurofilaments expressed as their index seem to contribute to the discrimination between patients with neuroinflammation and normal controls or AD patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LO1611" target="_blank" >LO1611: Udržitelnost pro Národní ústav duševního zdraví</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

161

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

286-295

Kód UT WoS článku

000418004800008

EID výsledku v databázi Scopus

2-s2.0-85030235183