Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F18%3A10427539" target="_blank" >RIV/00064203:_____/18:10427539 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/18:10383417 RIV/00216208:11150/18:10383417 RIV/00179906:_____/18:10383417

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QQKwcF7szq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QQKwcF7szq</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijporl.2018.09.007" target="_blank" >10.1016/j.ijporl.2018.09.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

Popis výsledku v původním jazyce

Aim: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. Methods: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. Results: Patients were stratified into groups with adenoids grades 1, 2 and 3 (&lt;1/3, 1/3-2/3 and &gt; 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P &lt; 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO &lt; 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P &lt; 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO &gt;77 nL/min. Conclusions: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.

Název v anglickém jazyce

Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

Popis výsledku anglicky

Aim: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. Methods: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. Results: Patients were stratified into groups with adenoids grades 1, 2 and 3 (&lt;1/3, 1/3-2/3 and &gt; 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P &lt; 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO &lt; 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P &lt; 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO &gt;77 nL/min. Conclusions: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30206 - Otorhinolaryngology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Pediatric Otorhinolaryngology

ISSN

0165-5876

e-ISSN

—

Svazek periodika

115

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

6-9

Kód UT WoS článku

000449898700002

EID výsledku v databázi Scopus

2-s2.0-85053524895