Correlation Between Disease Stage and the Presence of Viable Circulating Tumor Cells in Endometrial Cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F18%3A10427543" target="_blank" >RIV/00064203:_____/18:10427543 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/27283933:_____/18:00006339 RIV/61383082:_____/18:00000462 RIV/00216208:11110/18:10382992 RIV/00064173:_____/18:N0000013

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hR~zZ7yh6a" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hR~zZ7yh6a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12550" target="_blank" >10.21873/anticanres.12550</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Correlation Between Disease Stage and the Presence of Viable Circulating Tumor Cells in Endometrial Cancer

Popis výsledku v původním jazyce

Background/Aim: The presence of circulating tumor cells (CTCs) in the peripheral blood of patients with solid tumors is associated with a poor prognosis. However, there are limited data concerning the detection of CTCs in endometrial cancer (EC). The aim of this study was to evaluate the presence of CTCs in the peripheral blood of patients with EC. Materials and Methods: Peripheral blood samples from 92 patients who underwent a surgical procedure were evaluated using MetaCell (R) separation technology for CTCs. Results: CTCs were detected in 69 (75%) patients with EC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results showed that the technology applied in this study can efficiently capture viable tumor cells in the blood that can be cultured while maintaining their original phenotype. This paper discusses the first successful culturing of human circulating endometrial cancer cells for further downstream functional and molecular characterization.

Název v anglickém jazyce

Correlation Between Disease Stage and the Presence of Viable Circulating Tumor Cells in Endometrial Cancer

Popis výsledku anglicky

Background/Aim: The presence of circulating tumor cells (CTCs) in the peripheral blood of patients with solid tumors is associated with a poor prognosis. However, there are limited data concerning the detection of CTCs in endometrial cancer (EC). The aim of this study was to evaluate the presence of CTCs in the peripheral blood of patients with EC. Materials and Methods: Peripheral blood samples from 92 patients who underwent a surgical procedure were evaluated using MetaCell (R) separation technology for CTCs. Results: CTCs were detected in 69 (75%) patients with EC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results showed that the technology applied in this study can efficiently capture viable tumor cells in the blood that can be cultured while maintaining their original phenotype. This paper discusses the first successful culturing of human circulating endometrial cancer cells for further downstream functional and molecular characterization.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Svazek periodika

38

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

5

Strana od-do

2983-2987

Kód UT WoS článku

000449923200050

EID výsledku v databázi Scopus

2-s2.0-85046506490