Clinical and genotypic CMV drug resistance in HSCT recipients: a single center epidemiological and clinical data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10380748" target="_blank" >RIV/00064203:_____/19:10380748 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10380748 RIV/00216208:11150/19:10380748 RIV/00179906:_____/19:10380748

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=cCUpKvpeY9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=cCUpKvpeY9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41409-018-0257-7" target="_blank" >10.1038/s41409-018-0257-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical and genotypic CMV drug resistance in HSCT recipients: a single center epidemiological and clinical data

Popis výsledku v původním jazyce

We analysed the incidence, risk factors and the association between the treatment failure and viral resistance among 58 patients after allogeneic HSCT, who were treated for CMV reactivation/disease. The treatment failure (defined as a stable or increasing DNA viral load after 2 weeks of treatment) occurred in 9 patients (15.5%). The presence of ganciclovir-resistant CMV strain was proved in three of them (mutations L595F, M460I and A594V detected by nucleotide sequence analysis of the UL97 and UL54). The median time of treatment failure diagnosis was 70 days after HSCT. Patients with treatment failure were treated for a longer cumulative time than the patients susceptible to administrated virostatics (median of 90 vs 39 days, p = 0.003) and had a higher viral load peak (41,400 vs 4,160 cp/ml, p = 0.005). The viral load at the start of maintenance therapy was also higher (median of 1,305 vs 437 cp/ml, p = 0.0173) and the CMV disease occurred more often (p = 0.0152). Patients with prolonged CMV replication, virostatic therapy and high viral load should be monitored closely and testing of viral sensitivity to virostatic treatment should be performed in cases of suspected treatment failure.

Název v anglickém jazyce

Clinical and genotypic CMV drug resistance in HSCT recipients: a single center epidemiological and clinical data

Popis výsledku anglicky

We analysed the incidence, risk factors and the association between the treatment failure and viral resistance among 58 patients after allogeneic HSCT, who were treated for CMV reactivation/disease. The treatment failure (defined as a stable or increasing DNA viral load after 2 weeks of treatment) occurred in 9 patients (15.5%). The presence of ganciclovir-resistant CMV strain was proved in three of them (mutations L595F, M460I and A594V detected by nucleotide sequence analysis of the UL97 and UL54). The median time of treatment failure diagnosis was 70 days after HSCT. Patients with treatment failure were treated for a longer cumulative time than the patients susceptible to administrated virostatics (median of 90 vs 39 days, p = 0.003) and had a higher viral load peak (41,400 vs 4,160 cp/ml, p = 0.005). The viral load at the start of maintenance therapy was also higher (median of 1,305 vs 437 cp/ml, p = 0.0173) and the CMV disease occurred more often (p = 0.0152). Patients with prolonged CMV replication, virostatic therapy and high viral load should be monitored closely and testing of viral sensitivity to virostatic treatment should be performed in cases of suspected treatment failure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bone Marrow Transplantation

ISSN

0268-3369

e-ISSN

—

Svazek periodika

54

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

146-149

Kód UT WoS článku

000454884100020

EID výsledku v databázi Scopus

2-s2.0-85059492793