Intradialytic alkalization affects calcium balance and PTH level

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394154" target="_blank" >RIV/00064203:_____/19:10394154 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10394154

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=J2ttmga9HG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=J2ttmga9HG</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sdi.12746" target="_blank" >10.1111/sdi.12746</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Intradialytic alkalization affects calcium balance and PTH level

Popis výsledku v původním jazyce

We have read with great interest the excellent review of Basile et al1 and would like to add two more potential adverse effects of high dialysate bicarbonsate. We have recently published a pilot study evaluating the influence of dialysate bicarbonate concentration on intradialytic calcium balance and plasma PTH level changes in chronic dialysis patients. We found that dialysate bicarbonate influences plasma calcium, calcium balance, and intradialytic PTH levels. A higher dialysate bicarbonate decreases intradialytic losses of calcium and can result in actual calcium gains. These effects are primarily a result of the influence of alkalinization on plasma ionized calcium. As a patient is alkalized, plasma ionized calcium decreases which increases the diffusive gradient of ionized calcium from dialysate to the patient during the treatment. At the same time, intradialytic alkalinization leads to increased PTH secretion, also a consequence of the decreased plasma ionized calcium associated with the increased blood pH

Název v anglickém jazyce

Intradialytic alkalization affects calcium balance and PTH level

Popis výsledku anglicky

We have read with great interest the excellent review of Basile et al1 and would like to add two more potential adverse effects of high dialysate bicarbonsate. We have recently published a pilot study evaluating the influence of dialysate bicarbonate concentration on intradialytic calcium balance and plasma PTH level changes in chronic dialysis patients. We found that dialysate bicarbonate influences plasma calcium, calcium balance, and intradialytic PTH levels. A higher dialysate bicarbonate decreases intradialytic losses of calcium and can result in actual calcium gains. These effects are primarily a result of the influence of alkalinization on plasma ionized calcium. As a patient is alkalized, plasma ionized calcium decreases which increases the diffusive gradient of ionized calcium from dialysate to the patient during the treatment. At the same time, intradialytic alkalinization leads to increased PTH secretion, also a consequence of the decreased plasma ionized calcium associated with the increased blood pH

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Seminars in Dialysis

ISSN

0894-0959

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

85-86

Kód UT WoS článku

000455019600012

EID výsledku v databázi Scopus

2-s2.0-85054765505