Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394355" target="_blank" >RIV/00064203:_____/19:10394355 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10394355

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gcee3BcgGn" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gcee3BcgGn</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carpath.2019.02.004" target="_blank" >10.1016/j.carpath.2019.02.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair

Popis výsledku v původním jazyce

Objectives: The purpose of this study was to evaluate the microscopic structural abnormalities of the ascending aorta in infants with Tetralogy of Fallot (ToF) and compare them with aortic samples from control group of small children that died of other diseases. We aimed at identification of the specific histopathological changes associated with ToF and correlation of the severity of these changes with time to surgery and mean levels of saturation in the ToF group, and age at death in control group. Methods: The full-thickness ascending aortic wall sample was taken from 23 children with ToF at the time of surgical reconstruction (age spread 2 to 19 months) and evaluated by light microscopy. Corresponding samples were taken from 16 cadaverous cases of children with other diseases (0-76 months). The assessed morphological variables included elastic fiber fragmentation/loss, thinning and disorganisation, presence of laminar medial necrosis, intralamellar and translamellar mucoid extracellular matrix accumulations, smooth muscle cell disorganisation, presence of fibrosis, calcifications and neovascularisation and finally grade of overall medial degeneration. Results: No difference was found between the two groups in the individual morphological variables. However, there was a difference in the distribution of the grades of the overallmedial degeneration (P = .016). ToF group showed uniform mild degenerative changes, whereas control group harboured spectrum of changes ranging from normal to moderate. The presence of the given histopathological changes and their severity were associated neither with age at surgery or mean levels of saturation in ToF group, nor with the age at death in the control group. Conclusions: This study emphasizes the histopathological assessment of the bioptic samples of the ascending aorta during the surgical repair of ToF, since the patients demonstrating moderate or severe degenerative changes already in the early childhood may be in increased risk of the subsequent late complications. (C) 2019 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair

Popis výsledku anglicky

Objectives: The purpose of this study was to evaluate the microscopic structural abnormalities of the ascending aorta in infants with Tetralogy of Fallot (ToF) and compare them with aortic samples from control group of small children that died of other diseases. We aimed at identification of the specific histopathological changes associated with ToF and correlation of the severity of these changes with time to surgery and mean levels of saturation in the ToF group, and age at death in control group. Methods: The full-thickness ascending aortic wall sample was taken from 23 children with ToF at the time of surgical reconstruction (age spread 2 to 19 months) and evaluated by light microscopy. Corresponding samples were taken from 16 cadaverous cases of children with other diseases (0-76 months). The assessed morphological variables included elastic fiber fragmentation/loss, thinning and disorganisation, presence of laminar medial necrosis, intralamellar and translamellar mucoid extracellular matrix accumulations, smooth muscle cell disorganisation, presence of fibrosis, calcifications and neovascularisation and finally grade of overall medial degeneration. Results: No difference was found between the two groups in the individual morphological variables. However, there was a difference in the distribution of the grades of the overallmedial degeneration (P = .016). ToF group showed uniform mild degenerative changes, whereas control group harboured spectrum of changes ranging from normal to moderate. The presence of the given histopathological changes and their severity were associated neither with age at surgery or mean levels of saturation in ToF group, nor with the age at death in the control group. Conclusions: This study emphasizes the histopathological assessment of the bioptic samples of the ascending aorta during the surgical repair of ToF, since the patients demonstrating moderate or severe degenerative changes already in the early childhood may be in increased risk of the subsequent late complications. (C) 2019 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cardiovascular Pathology

ISSN

1054-8807

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

May - June

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

59-64

Kód UT WoS článku

000466612700011

EID výsledku v databázi Scopus

2-s2.0-85063052110