Generalized quasiperiodic epileptiform activity in sleep is associated with cognitive impairment in children with drug-resistant focal lesional epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10398905" target="_blank" >RIV/00064203:_____/19:10398905 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/19:00337922 RIV/00216208:11130/19:10398905

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Xh8wGlCkDI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Xh8wGlCkDI</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/epi.16362" target="_blank" >10.1111/epi.16362</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Generalized quasiperiodic epileptiform activity in sleep is associated with cognitive impairment in children with drug-resistant focal lesional epilepsy

Popis výsledku v původním jazyce

Objective To evaluate the impact of generalized quasiperiodic epileptiform discharges (&quot;hurdles&quot;) observed in non-rapid eye movement (NREM) sleep on cognitive function in children with intractable focal epilepsy. &quot;Hurdles&quot; pattern does not meet the criteria of the electrical status epilepticus in slow-wave sleep (ESES). Methods In a retrospective analysis, 24 patients with &quot;hurdles&quot; and their 24 peers matched for demographic and epilepsy-related variables were compared in terms of neuropsychological domains and electroencephalography (EEG)-derived quantifiers. Both &quot;hurdles&quot; and controls were children between 2 and 19 years of age who had intractable focal epilepsy evaluated as candidates of resective epilepsy surgery. Results Full-scale intelligence quotient/developmental quotient (FSIQ/DQ) (P = .002) and visuoconstructional skills (P = .004) were significantly lower in children with &quot;hurdles&quot; compared to controls. Patients with &quot;hurdles&quot; presented with higher interictal spike indexes in sleep (P &lt; .001, median difference -0.9, 95% confidence interval [CI] -1.4, -0.6) and wakefulness (P &lt; .001, median difference -0.3, 95% CI -0.5, -1). Relative time of sleep spindles in NREM sleep was significantly reduced (P &lt; .001, median difference 0.1, 95% CI 0.0, 0.1) in the &quot;hurdles&quot; group. The time proportion of sleep spindles represented a significant positive (P = .008) and spike index of generalized spikes in sleep a significant negative explanatory variable (P = .004) of FSIQ/DQ scores. The proportion of seizure-free patients 2 years after epilepsy surgery did not differ significantly between the two groups (P = .19). Significance Although the &quot;hurdles&quot; pattern does not fulfill the criteria of ESES, it is associated with a pronounced cognitive dysfunction. Disturbed sleep structure marked by reduced sleep spindles and generalized spiking in sleep is associated with worse cognitive performance. Despite having a generalized nature, we did not find a lower probability of postsurgical seizure freedom in patients with &quot;hurdles&quot; pattern.

Název v anglickém jazyce

Generalized quasiperiodic epileptiform activity in sleep is associated with cognitive impairment in children with drug-resistant focal lesional epilepsy

Popis výsledku anglicky

Objective To evaluate the impact of generalized quasiperiodic epileptiform discharges (&quot;hurdles&quot;) observed in non-rapid eye movement (NREM) sleep on cognitive function in children with intractable focal epilepsy. &quot;Hurdles&quot; pattern does not meet the criteria of the electrical status epilepticus in slow-wave sleep (ESES). Methods In a retrospective analysis, 24 patients with &quot;hurdles&quot; and their 24 peers matched for demographic and epilepsy-related variables were compared in terms of neuropsychological domains and electroencephalography (EEG)-derived quantifiers. Both &quot;hurdles&quot; and controls were children between 2 and 19 years of age who had intractable focal epilepsy evaluated as candidates of resective epilepsy surgery. Results Full-scale intelligence quotient/developmental quotient (FSIQ/DQ) (P = .002) and visuoconstructional skills (P = .004) were significantly lower in children with &quot;hurdles&quot; compared to controls. Patients with &quot;hurdles&quot; presented with higher interictal spike indexes in sleep (P &lt; .001, median difference -0.9, 95% confidence interval [CI] -1.4, -0.6) and wakefulness (P &lt; .001, median difference -0.3, 95% CI -0.5, -1). Relative time of sleep spindles in NREM sleep was significantly reduced (P &lt; .001, median difference 0.1, 95% CI 0.0, 0.1) in the &quot;hurdles&quot; group. The time proportion of sleep spindles represented a significant positive (P = .008) and spike index of generalized spikes in sleep a significant negative explanatory variable (P = .004) of FSIQ/DQ scores. The proportion of seizure-free patients 2 years after epilepsy surgery did not differ significantly between the two groups (P = .19). Significance Although the &quot;hurdles&quot; pattern does not fulfill the criteria of ESES, it is associated with a pronounced cognitive dysfunction. Disturbed sleep structure marked by reduced sleep spindles and generalized spiking in sleep is associated with worse cognitive performance. Despite having a generalized nature, we did not find a lower probability of postsurgical seizure freedom in patients with &quot;hurdles&quot; pattern.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV19-04-00369" target="_blank" >NV19-04-00369: Stratifikace pacientů s fokální kortikální dysplázií k optimalizaci epileptochirurgie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epilepsia

ISSN

0013-9580

e-ISSN

—

Svazek periodika

60

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

2263-2276

Kód UT WoS článku

000489937000001

EID výsledku v databázi Scopus

2-s2.0-85074074848