Determinants of utilization of cryopreservation of germ cells in adolescent cancer patients in four European countries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F20%3A10410862" target="_blank" >RIV/00064203:_____/20:10410862 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00072645 RIV/00216208:11130/20:10410862

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HZCTY6_iKJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HZCTY6_iKJ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00431-019-03459-9" target="_blank" >10.1007/s00431-019-03459-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Determinants of utilization of cryopreservation of germ cells in adolescent cancer patients in four European countries

Popis výsledku v původním jazyce

Infertility is a relevant late-effect following cancer treatment; yet, a large proportion of survivors cannot recall having been informed of this risk. In an intervention study, we examined if and how supportive patient information material on fertility/fertility-preserving measures influences utilization of cryopreservation in adolescent cancer patients. The control group, recruited 03/2014-01/2016, received the usual patient education at initial diagnosis. The intervention group, recruited 04/2016-10/2017, received patient education supported by a fertility flyer and brochure. Patients and parents were each asked questions on utilization of cryopreservation in a questionnaire 3 and 6 months after initial diagnosis. Patient core and therapy data were obtained from medical records. Overall, cryopreservation rates showed no significant difference between the control (32.7%, n = 37/113) and intervention group (36.6%, n = 37/101). In the control group, cryopreservation was associated with gender (OR 0.100, CI 0.023-0.427), age (OR 1.559, CI 1.077-2.258) and recalling information on fertility protection (OR 33.663, CI 2.100-539.574); in the intervention group, cryopreservation was related to gender (OR 0.093, CI 0.026-0.330) and the estimated infertility risk (OR 43.665, CI 2.157-883.974). Conclusion: Cryopreservation rates did not overall increase following the intervention; however, the individual risk seemed to be brought into attention more: Those at risk, including younger patients, cryopreserved at higher rates. What is Known: Infertility is a relevant late-effect following adolescent cancer. Guidelines recommend to offer fertility protection before cancer treatment. A relevant proportion of adolescents with cancer are not aware of this risk. Fertility protection seems under-used in cancer patients at risk for infertility. What is New: Information material on fertility and protection in adolescents did not increase overall rates of cryopreservation. Cryopreservation rates were improved according to individual risk for infertility. Our flyers and brochures on fertility in cancer patients are available in various languages.

Název v anglickém jazyce

Determinants of utilization of cryopreservation of germ cells in adolescent cancer patients in four European countries

Popis výsledku anglicky

Infertility is a relevant late-effect following cancer treatment; yet, a large proportion of survivors cannot recall having been informed of this risk. In an intervention study, we examined if and how supportive patient information material on fertility/fertility-preserving measures influences utilization of cryopreservation in adolescent cancer patients. The control group, recruited 03/2014-01/2016, received the usual patient education at initial diagnosis. The intervention group, recruited 04/2016-10/2017, received patient education supported by a fertility flyer and brochure. Patients and parents were each asked questions on utilization of cryopreservation in a questionnaire 3 and 6 months after initial diagnosis. Patient core and therapy data were obtained from medical records. Overall, cryopreservation rates showed no significant difference between the control (32.7%, n = 37/113) and intervention group (36.6%, n = 37/101). In the control group, cryopreservation was associated with gender (OR 0.100, CI 0.023-0.427), age (OR 1.559, CI 1.077-2.258) and recalling information on fertility protection (OR 33.663, CI 2.100-539.574); in the intervention group, cryopreservation was related to gender (OR 0.093, CI 0.026-0.330) and the estimated infertility risk (OR 43.665, CI 2.157-883.974). Conclusion: Cryopreservation rates did not overall increase following the intervention; however, the individual risk seemed to be brought into attention more: Those at risk, including younger patients, cryopreserved at higher rates. What is Known: Infertility is a relevant late-effect following adolescent cancer. Guidelines recommend to offer fertility protection before cancer treatment. A relevant proportion of adolescents with cancer are not aware of this risk. Fertility protection seems under-used in cancer patients at risk for infertility. What is New: Information material on fertility and protection in adolescents did not increase overall rates of cryopreservation. Cryopreservation rates were improved according to individual risk for infertility. Our flyers and brochures on fertility in cancer patients are available in various languages.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pediatrics

ISSN

0340-6199

e-ISSN

—

Svazek periodika

179

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

51-60

Kód UT WoS článku

000510430300006

EID výsledku v databázi Scopus

2-s2.0-85073933687