Mortality in Children Treated With Maintenance Peritoneal Dialysis: Findings From the International Pediatric Peritoneal Dialysis Network Registry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10422595" target="_blank" >RIV/00064203:_____/21:10422595 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/21:10422595

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=zbTVJJUCSY" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=zbTVJJUCSY</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/j.ajkd.2020.11.031" target="_blank" >10.1053/j.ajkd.2020.11.031</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mortality in Children Treated With Maintenance Peritoneal Dialysis: Findings From the International Pediatric Peritoneal Dialysis Network Registry

Popis výsledku v původním jazyce

RATIONALE &amp; OBJECTIVE: Research on pediatric kidney replacement therapy (KRT) has primarily focused on Europe and North America. In this study, we aimed to describe the mortality risk of children treated with maintenance peritoneal dialysis (MPD) in different parts of the world and characterize the associated demographic and macro-economic factors. STUDY DESIGN: Prospective cohort study. SETTING &amp; PARTICIPANTS: We evaluated patients aged &lt;19 years at inclusion into the International Pediatric Peritoneal Dialysis Network registry, who initiated MPD between 1996-2017. EXPOSURES: The primary exposure was region (Asia, Western Europe, Eastern Europe, Latin America, North America, and Oceania). Other demographic, clinical and macro-economic (four income groups based on Gross National Income) factors were studied as exposures. OUTCOMES: All-cause MPD mortality. ANALYTICAL APPROACH: Patients were followed for three years. Mortality rates in different regions and income groups were calculated. Cause-specific hazards models with random effects were fit to calculate the proportional change in variance for factors that could explain variation in mortality rates. RESULTS: A total of 2,956 patients with a median age of 7.8 years at the start of KRT were included. After three years, the overall probability of death was 5%, ranging from 2% in North America to 9% in Eastern Europe. Mortality rates were higher in low-income countries than in high-income countries. Income category explained 50.1% of the variance in mortality risk between regions. Other explanatory factors included peritoneal dialysis modality at start (22.5%) and body mass index (11.1%). LIMITATIONS: The interpretation of interregional survival differences as found in this study may be hampered by selection bias. CONCLUSION: This study shows that the overall three-year patient survival on pediatric MPD is high, and that country income is associated with patient survival.

Název v anglickém jazyce

Mortality in Children Treated With Maintenance Peritoneal Dialysis: Findings From the International Pediatric Peritoneal Dialysis Network Registry

Popis výsledku anglicky

RATIONALE &amp; OBJECTIVE: Research on pediatric kidney replacement therapy (KRT) has primarily focused on Europe and North America. In this study, we aimed to describe the mortality risk of children treated with maintenance peritoneal dialysis (MPD) in different parts of the world and characterize the associated demographic and macro-economic factors. STUDY DESIGN: Prospective cohort study. SETTING &amp; PARTICIPANTS: We evaluated patients aged &lt;19 years at inclusion into the International Pediatric Peritoneal Dialysis Network registry, who initiated MPD between 1996-2017. EXPOSURES: The primary exposure was region (Asia, Western Europe, Eastern Europe, Latin America, North America, and Oceania). Other demographic, clinical and macro-economic (four income groups based on Gross National Income) factors were studied as exposures. OUTCOMES: All-cause MPD mortality. ANALYTICAL APPROACH: Patients were followed for three years. Mortality rates in different regions and income groups were calculated. Cause-specific hazards models with random effects were fit to calculate the proportional change in variance for factors that could explain variation in mortality rates. RESULTS: A total of 2,956 patients with a median age of 7.8 years at the start of KRT were included. After three years, the overall probability of death was 5%, ranging from 2% in North America to 9% in Eastern Europe. Mortality rates were higher in low-income countries than in high-income countries. Income category explained 50.1% of the variance in mortality risk between regions. Other explanatory factors included peritoneal dialysis modality at start (22.5%) and body mass index (11.1%). LIMITATIONS: The interpretation of interregional survival differences as found in this study may be hampered by selection bias. CONCLUSION: This study shows that the overall three-year patient survival on pediatric MPD is high, and that country income is associated with patient survival.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Kidney Diseases

ISSN

0272-6386

e-ISSN

—

Svazek periodika

78

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

380-390

Kód UT WoS článku

000686900900011

EID výsledku v databázi Scopus

2-s2.0-85105360262