Kidney Transplantation in Small Children: Association Between Body Weight and Outcome - A Report From the ESPN/ERA-EDTA Registry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10426101" target="_blank" >RIV/00064203:_____/22:10426101 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/22:10426101 RIV/00216208:11140/22:10426101

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NM97T.zDpl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NM97T.zDpl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/TP.0000000000003771" target="_blank" >10.1097/TP.0000000000003771</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Kidney Transplantation in Small Children: Association Between Body Weight and Outcome - A Report From the ESPN/ERA-EDTA Registry

Popis výsledku v původním jazyce

BACKGROUND: Many centers accept a minimum body weight of 10 kg as threshold for kidney transplantation (Tx) in children. As solid evidence for clinical outcomes in multinational studies is lacking, we evaluated practices and outcomes in European children weighing below 10 kg at Tx. METHODS: Data were obtained from the ESPN/ERA-EDTA Registry on all children who started kidney replacement therapy (KRT) at &lt;2.5 years of age and received a Tx between 2000 and 2016. Weight at Tx was categorized (&lt;10 kg versus &gt;=10 kg) and Cox regression analysis was used to evaluate its association with graft survival. RESULTS: One hundred of the 601 children received a Tx below a weight of 10 kg during the study period. Primary renal disease groups were equal, but Tx &lt;10 kg patients had lower pre-Tx weight gain per year (0.2 kg versus 2.1 kg; p&lt;0.001) and had a higher preemptive Tx rate (23% versus 7%; p&lt;0.001). No differences were found for posttransplant estimated glomerular filtration rates (eGFR) trajectories (p=0.23).The graft failure risk was higher in Tx &lt;10 kg patients at 1 year (graft survival: 90% versus 95%; aHR: 3.84, 95% CI: 1.24-11.84), but not at 5 years (aHR: 1.71, 95% CI: 0.68-4.30). CONCLUSIONS: Despite a lower 1-year graft survival rate, graft function and survival at 5 years were identical in Tx &lt;10 kg patients when compared with Tx &gt;=10 kg patients. Our results suggest that early transplantation should be offered to a carefully selected group of patients weighing &lt;10 kg.

Název v anglickém jazyce

Kidney Transplantation in Small Children: Association Between Body Weight and Outcome - A Report From the ESPN/ERA-EDTA Registry

Popis výsledku anglicky

BACKGROUND: Many centers accept a minimum body weight of 10 kg as threshold for kidney transplantation (Tx) in children. As solid evidence for clinical outcomes in multinational studies is lacking, we evaluated practices and outcomes in European children weighing below 10 kg at Tx. METHODS: Data were obtained from the ESPN/ERA-EDTA Registry on all children who started kidney replacement therapy (KRT) at &lt;2.5 years of age and received a Tx between 2000 and 2016. Weight at Tx was categorized (&lt;10 kg versus &gt;=10 kg) and Cox regression analysis was used to evaluate its association with graft survival. RESULTS: One hundred of the 601 children received a Tx below a weight of 10 kg during the study period. Primary renal disease groups were equal, but Tx &lt;10 kg patients had lower pre-Tx weight gain per year (0.2 kg versus 2.1 kg; p&lt;0.001) and had a higher preemptive Tx rate (23% versus 7%; p&lt;0.001). No differences were found for posttransplant estimated glomerular filtration rates (eGFR) trajectories (p=0.23).The graft failure risk was higher in Tx &lt;10 kg patients at 1 year (graft survival: 90% versus 95%; aHR: 3.84, 95% CI: 1.24-11.84), but not at 5 years (aHR: 1.71, 95% CI: 0.68-4.30). CONCLUSIONS: Despite a lower 1-year graft survival rate, graft function and survival at 5 years were identical in Tx &lt;10 kg patients when compared with Tx &gt;=10 kg patients. Our results suggest that early transplantation should be offered to a carefully selected group of patients weighing &lt;10 kg.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation

ISSN

0041-1337

e-ISSN

1534-6080

Svazek periodika

106

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

607-614

Kód UT WoS článku

000759088200041

EID výsledku v databázi Scopus

2-s2.0-85125019619