PD-L1 and PD-1 Expression in Thyroid Follicular Epithelial Dysplasia: Hashimoto Thyroiditis Related Atypia and Potential Papillary Carcinoma Precursor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10441407" target="_blank" >RIV/00064203:_____/22:10441407 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10441407 RIV/00216208:11140/22:10441407

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lMYqOubbCY" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lMYqOubbCY</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/apm.13218" target="_blank" >10.1111/apm.13218</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PD-L1 and PD-1 Expression in Thyroid Follicular Epithelial Dysplasia: Hashimoto Thyroiditis Related Atypia and Potential Papillary Carcinoma Precursor

Popis výsledku v původním jazyce

PD-L1 and PD-1 Expression in Thyroid Follicular Epithelial Dysplasia: Hashimoto Thyroiditis Related Atypia and Potential Papillary Carcinoma Precursor Programmed cell death ligand (PD-L1)/PD-1 expression has been studied in a variety of cancers and blockage of PD-L1/PD-1 pathway is a cornerstone of immunotherapy. We studied PD-L1/PD-1 immunohistochemical expression in 47 thyroid gland specimens in groups of 1) Hashimoto thyroiditis (HT) only, 2) HT and follicular epithelial dysplasia (FED) and 3) HT, FED and papillary thyroid carcinoma (PTC). PD-1 positivity was found in immune cells, namely in lymphocytes, macrophages, and plasma cells with mean values for lymphocytes and macrophages 9% in HT group, 4% in FED group, and 4% in PTC group. PD-L1 positivity was identified in both immune cells and in the normal epithelial cells. In the HT group, mean PD-L1 staining on immune cells was 6%, in FED group 5%, and in PTC group 7%. The mean PD-L1 staining on the epithelial cells in the inflammatory parenchyma was 11.7% in HT, 13.4% in FED and 8.3% in PTC group. The mean PD-L1 staining of FED foci was 47.2% in FED group and 33.6% in PTC group. The mean tumor proportion score (TPS) was 10.4% and the mean combined positive score (CPS) was 15.5. At the moment, PTC is not a target of immunotherapy. However, understanding the complex issue of concurrent inflammation and autoimmunity can importantly influence the cancer treatment in future.

Název v anglickém jazyce

PD-L1 and PD-1 Expression in Thyroid Follicular Epithelial Dysplasia: Hashimoto Thyroiditis Related Atypia and Potential Papillary Carcinoma Precursor

Popis výsledku anglicky

PD-L1 and PD-1 Expression in Thyroid Follicular Epithelial Dysplasia: Hashimoto Thyroiditis Related Atypia and Potential Papillary Carcinoma Precursor Programmed cell death ligand (PD-L1)/PD-1 expression has been studied in a variety of cancers and blockage of PD-L1/PD-1 pathway is a cornerstone of immunotherapy. We studied PD-L1/PD-1 immunohistochemical expression in 47 thyroid gland specimens in groups of 1) Hashimoto thyroiditis (HT) only, 2) HT and follicular epithelial dysplasia (FED) and 3) HT, FED and papillary thyroid carcinoma (PTC). PD-1 positivity was found in immune cells, namely in lymphocytes, macrophages, and plasma cells with mean values for lymphocytes and macrophages 9% in HT group, 4% in FED group, and 4% in PTC group. PD-L1 positivity was identified in both immune cells and in the normal epithelial cells. In the HT group, mean PD-L1 staining on immune cells was 6%, in FED group 5%, and in PTC group 7%. The mean PD-L1 staining on the epithelial cells in the inflammatory parenchyma was 11.7% in HT, 13.4% in FED and 8.3% in PTC group. The mean PD-L1 staining of FED foci was 47.2% in FED group and 33.6% in PTC group. The mean tumor proportion score (TPS) was 10.4% and the mean combined positive score (CPS) was 15.5. At the moment, PTC is not a target of immunotherapy. However, understanding the complex issue of concurrent inflammation and autoimmunity can importantly influence the cancer treatment in future.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30206 - Otorhinolaryngology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

APMIS

ISSN

0903-4641

e-ISSN

1600-0463

Svazek periodika

130

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

276-283

Kód UT WoS článku

000767947700001

EID výsledku v databázi Scopus

2-s2.0-85126084752