Sex and gender differences in the neurological and neuropsychiatric symptoms of long COVID: a narrative review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10442998" target="_blank" >RIV/00064203:_____/22:10442998 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/22:10442998

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sIOmq7i_jR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sIOmq7i_jR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1723/3769.37563" target="_blank" >10.1723/3769.37563</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sex and gender differences in the neurological and neuropsychiatric symptoms of long COVID: a narrative review

Popis výsledku v původním jazyce

COVID-19 was deemed a global pandemic in March 2020 and, since then, millions of people have been affected worldwide. Now, nearly two years later, the long-term sequelae of the virus are becoming increasingly appar-ent. This novel form of the disease, commonly referred to as &quot;long COVID&quot;, appears to be more common in females than in males. In this narrative review, we consulted published studies on long COVID reporting sex-disaggregated findings and discuss the possible mechanisms underlying potential sex differences. We found that females are more likely to experience milder acute COVID-19 disease, lower mortality, and a higher number of persistent physical, cognitive, neu-rological, and neuropsychiatric symptoms compared to males. Stronger innate and adaptive immune responses in females may be one of the mechanisms underlying this sex difference. The arrival of COVID-19 presents a unique occa-sion to study sex differences in the prevalence, symptomatol-ogy, risk factors, and disease progression shortly after disease emergence. We argue that advantage must be taken of this opportunity to provide researchers with the proper tools to address sex differences in COVID-19 and effectively tailor assessments and treatments toward individual needs.

Název v anglickém jazyce

Sex and gender differences in the neurological and neuropsychiatric symptoms of long COVID: a narrative review

Popis výsledku anglicky

COVID-19 was deemed a global pandemic in March 2020 and, since then, millions of people have been affected worldwide. Now, nearly two years later, the long-term sequelae of the virus are becoming increasingly appar-ent. This novel form of the disease, commonly referred to as &quot;long COVID&quot;, appears to be more common in females than in males. In this narrative review, we consulted published studies on long COVID reporting sex-disaggregated findings and discuss the possible mechanisms underlying potential sex differences. We found that females are more likely to experience milder acute COVID-19 disease, lower mortality, and a higher number of persistent physical, cognitive, neu-rological, and neuropsychiatric symptoms compared to males. Stronger innate and adaptive immune responses in females may be one of the mechanisms underlying this sex difference. The arrival of COVID-19 presents a unique occa-sion to study sex differences in the prevalence, symptomatol-ogy, risk factors, and disease progression shortly after disease emergence. We argue that advantage must be taken of this opportunity to provide researchers with the proper tools to address sex differences in COVID-19 and effectively tailor assessments and treatments toward individual needs.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Italian Journal of Gender-Specific Medicine

ISSN

2421-7212

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

11

Strana od-do

18-28

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85127497536