The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10446165" target="_blank" >RIV/00064203:_____/22:10446165 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/22:10446165 RIV/00216224:14110/22:00128440

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fOaxo.WvpY" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fOaxo.WvpY</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/curroncol29080453" target="_blank" >10.3390/curroncol29080453</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

Popis výsledku v původním jazyce

CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p &lt; 0.001, 29.7% vs. 2.5%), low birth weight (p &lt; 0.001; OR = 3.035, 95%-CI = 1.615-5.706), and preterm birth (p &lt; 0.001; OR = 2.499, 95%-CI = 1.401-4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.

Název v anglickém jazyce

The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

Popis výsledku anglicky

CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p &lt; 0.001, 29.7% vs. 2.5%), low birth weight (p &lt; 0.001; OR = 3.035, 95%-CI = 1.615-5.706), and preterm birth (p &lt; 0.001; OR = 2.499, 95%-CI = 1.401-4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Oncology

ISSN

1198-0052

e-ISSN

1718-7729

Svazek periodika

29

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

15

Strana od-do

5748-5762

Kód UT WoS článku

000845993000001

EID výsledku v databázi Scopus

2-s2.0-85136461774