Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10450557" target="_blank" >RIV/00064203:_____/23:10450557 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/23:00574564 RIV/61388971:_____/23:00574564 RIV/00216208:11130/23:10450557
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hY8CvWdQkN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hY8CvWdQkN</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/bloodadvances.2021006431" target="_blank" >10.1182/bloodadvances.2021006431</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
Popis výsledku v původním jazyce
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse of ALL is often associated with resistance to ASNase and itsmechanisms are not fully understood. The cytotoxic effect of ASNase relies on depleting exogenousasparagine (Asn) and glutamine (Gln), inducing apoptosis in leukemic cells because of their reducedcapability of Asn synthesis. Our previous in vitro data demonstrated that ASNase triggers metabolicreprogramming of leukemic cells which impedes the anti-leukemic effect. Metabolic processes ofleukemic cells have been shown to be altered by the environment of the bone marrow (BM) whichmay contribute to chemoresistance. Herein, we investigated the impact of BM attributes oncellular metabolic processes of leukemic cells in order to demonstrate the more complex picture ofASNase-driven metabolic rewiring and its role in the mechanism of resistance.
Název v anglickém jazyce
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
Popis výsledku anglicky
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse of ALL is often associated with resistance to ASNase and itsmechanisms are not fully understood. The cytotoxic effect of ASNase relies on depleting exogenousasparagine (Asn) and glutamine (Gln), inducing apoptosis in leukemic cells because of their reducedcapability of Asn synthesis. Our previous in vitro data demonstrated that ASNase triggers metabolicreprogramming of leukemic cells which impedes the anti-leukemic effect. Metabolic processes ofleukemic cells have been shown to be altered by the environment of the bone marrow (BM) whichmay contribute to chemoresistance. Herein, we investigated the impact of BM attributes oncellular metabolic processes of leukemic cells in order to demonstrate the more complex picture ofASNase-driven metabolic rewiring and its role in the mechanism of resistance.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30205 - Hematology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Blood Advances
ISSN
2473-9529
e-ISSN
2473-9537
Svazek periodika
7
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
2228-2236
Kód UT WoS článku
001002224300001
EID výsledku v databázi Scopus
2-s2.0-85162919169