Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10458588" target="_blank" >RIV/00064203:_____/23:10458588 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10458588

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wMpEgMXIFf" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wMpEgMXIFf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2022.281788" target="_blank" >10.3324/haematol.2022.281788</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Popis výsledku v původním jazyce

Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all patients. Treatment intensity depends on the initial CNS status. In trial AIEOP-BFM ALL 2009, patients with cytomorphological detection of leukemic blasts in initial cerebrospinal fluid were classified as CNS2 or CNS3 and received five intrathecal doses of methotrexate in induction therapy compared to patients with CNS1 status (no blasts detected) who received three doses. The impact of additional intrathecal methotrexate on systemic toxicity in induction therapy is unknown. Between June 01, 2010 and February 28, 2017, 6136 patients at the age of 1 to 17 years with ALL were enrolled onto the trial AIEOP-BFM ALL 2009. The effect of three versus five doses of intrathecal methotrexate during induction therapy on the incidence of severe infectious complications was analyzed. Among 4706 patients treated with three intrathecal methotrexate doses, 77 (1.6%) had a lifethreatening infection during induction as compared to 59 of 1350 (4.4%) patients treated with five doses (p.

Název v anglickém jazyce

Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Popis výsledku anglicky

Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all patients. Treatment intensity depends on the initial CNS status. In trial AIEOP-BFM ALL 2009, patients with cytomorphological detection of leukemic blasts in initial cerebrospinal fluid were classified as CNS2 or CNS3 and received five intrathecal doses of methotrexate in induction therapy compared to patients with CNS1 status (no blasts detected) who received three doses. The impact of additional intrathecal methotrexate on systemic toxicity in induction therapy is unknown. Between June 01, 2010 and February 28, 2017, 6136 patients at the age of 1 to 17 years with ALL were enrolled onto the trial AIEOP-BFM ALL 2009. The effect of three versus five doses of intrathecal methotrexate during induction therapy on the incidence of severe infectious complications was analyzed. Among 4706 patients treated with three intrathecal methotrexate doses, 77 (1.6%) had a lifethreatening infection during induction as compared to 59 of 1350 (4.4%) patients treated with five doses (p.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Haematologica

ISSN

0390-6078

e-ISSN

1592-8721

Svazek periodika

108

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

9

Strana od-do

3278-3286

Kód UT WoS článku

001163819400003

EID výsledku v databázi Scopus

2-s2.0-85178651465