Baseline reticular basement membrane morphology is related to subsequent spirometry deterioration in pediatric chronic airway inflammation: A follow-up study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10464879" target="_blank" >RIV/00064203:_____/23:10464879 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10464879 RIV/00216208:11320/23:10464879

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qoiwC65q4h" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qoiwC65q4h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1152/ajplung.00058.2023" target="_blank" >10.1152/ajplung.00058.2023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Baseline reticular basement membrane morphology is related to subsequent spirometry deterioration in pediatric chronic airway inflammation: A follow-up study

Popis výsledku v původním jazyce

Reticular basement membrane (RBM) thickening may occur in children with allergic bronchial asthma (BA), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Its functional consequences remain unknown. We investigated the relationship between baseline RBM thickness and subsequent spirometry. In our cohort follow-up study, patients aged 3-18 years with BA, CF, and PCD and controls underwent baseline lung clearance index (LCI) measurement, spirometry, and endobronchial biopsy sampling. Total RBM and collagen IV-positive layer thickness were measured. Trends in forced vital capacity (FVC), forced expired volume in 1 second (FEV(1)), and FEV(1)/FVC were analyzed during follow-up, and their relationship to baseline characteristics was studied using univariate analysis and multiple regression models. Complete baseline data were available in 19 BA, 30 CF, 25 PCD patients, and 19 controls. The RBM was thicker in BA (6.33+-1.22 μm), CF (5.60+-1.39 μm), and PCD (6.50+-1.87 μm) than in controls (3.29+-0.55 μm) (all p&lt;0.001). The LCI was higher in CF (15.32+-4.58, p&lt;0.001) and PCD (10.97+-2.46, p=0.002) than in controls (7.44+-0.43). The median follow-up times were 3.6, 4.8, 5.7, and 1.9 years in BA, CF, PCD, and controls respectively. The Z-scores of FEV(1) and FEV(1)/FVC deteriorated significantly in all groups except in controls. In CF and PCD, trends in FEV(1) z-scores correlated with baseline LCI and RBM; in BA, it correlated with collagen IV. In multiple regression models, RBM morphology and ventilation inhomogeneity could predict up to 84.4% of variability in spirometry trends. In conclusion, baseline LCI value and RBM morphology may predict trends in subsequent spirometry.

Název v anglickém jazyce

Baseline reticular basement membrane morphology is related to subsequent spirometry deterioration in pediatric chronic airway inflammation: A follow-up study

Popis výsledku anglicky

Reticular basement membrane (RBM) thickening may occur in children with allergic bronchial asthma (BA), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Its functional consequences remain unknown. We investigated the relationship between baseline RBM thickness and subsequent spirometry. In our cohort follow-up study, patients aged 3-18 years with BA, CF, and PCD and controls underwent baseline lung clearance index (LCI) measurement, spirometry, and endobronchial biopsy sampling. Total RBM and collagen IV-positive layer thickness were measured. Trends in forced vital capacity (FVC), forced expired volume in 1 second (FEV(1)), and FEV(1)/FVC were analyzed during follow-up, and their relationship to baseline characteristics was studied using univariate analysis and multiple regression models. Complete baseline data were available in 19 BA, 30 CF, 25 PCD patients, and 19 controls. The RBM was thicker in BA (6.33+-1.22 μm), CF (5.60+-1.39 μm), and PCD (6.50+-1.87 μm) than in controls (3.29+-0.55 μm) (all p&lt;0.001). The LCI was higher in CF (15.32+-4.58, p&lt;0.001) and PCD (10.97+-2.46, p=0.002) than in controls (7.44+-0.43). The median follow-up times were 3.6, 4.8, 5.7, and 1.9 years in BA, CF, PCD, and controls respectively. The Z-scores of FEV(1) and FEV(1)/FVC deteriorated significantly in all groups except in controls. In CF and PCD, trends in FEV(1) z-scores correlated with baseline LCI and RBM; in BA, it correlated with collagen IV. In multiple regression models, RBM morphology and ventilation inhomogeneity could predict up to 84.4% of variability in spirometry trends. In conclusion, baseline LCI value and RBM morphology may predict trends in subsequent spirometry.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Physiology - Lung Cellular and Molecular Physiology

ISSN

1040-0605

e-ISSN

1522-1504

Svazek periodika

325

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"L125"-"L134"

Kód UT WoS článku

001034287400004

EID výsledku v databázi Scopus

2-s2.0-85164625268