Clinical Features and Natural History of Paediatric Patients with Ulcerative Proctitis: A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10465702" target="_blank" >RIV/00064203:_____/23:10465702 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10465702

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xpbTa-Xx6u" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xpbTa-Xx6u</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ecco-jcc/jjad111" target="_blank" >10.1093/ecco-jcc/jjad111</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical Features and Natural History of Paediatric Patients with Ulcerative Proctitis: A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN

Popis výsledku v původním jazyce

BACKGROUND AND AIMS: Ulcerative proctitis (UP) is an uncommon presentation in paediatric patients with ulcerative colitis. We aimed to characterize the clinical features and natural history of UP in children, and identify predictors of poor outcomes. METHODS: Retrospective study involving 37 sites affiliated with the IBD Porto Group of ESPGHAN. Data were collected from patients aged&lt;18 years diagnosed with UP between 01/01/2016-31/12/2020. RESULTS: We identified 196 patients with UP (median age at diagnosis 14.6 [IQR 12.5-16.0] years), with a median follow-up of 2.7 (IQR 1.7-3.8) years. The most common presenting symptoms were bloody stools (95%), abdominal pain (61%) and diarrhea )47%). At diagnosis, the median paediatric ulcerative colitis activity index (PUCAI) score was 25 (IQR 20-35), but most patients exhibited moderate-severe endoscopic inflammation. By the end-of-induction, 5-aminosalicylic acid administration orally, topically or both resulted in clinical remission rates of 48%, 48% and 73%, respectively. The rates of treatment escalation to biologics at 1, 3 and 5 years were 10%, 22% and 43%, respectively. In multivariate analysis, the PUCAI score at diagnosis was significantly associated with initiation of systemic steroids, or biologics, and subsequent acute severe colitis events and IBD-associated admission, with a score&gt;=35 providing increased risk for poor outcomes. By the end of follow-up, 3.1% of patients underwent colectomy. Patients with proximal disease progression (48%) had significantly higher rates of cecal patch at diagnosis and higher PUCAI score by end-of-induction, compared to those without progression. CONCLUSION: Paediatric patients with UP exhibit high rates of treatment escalation and proximal disease extension.

Název v anglickém jazyce

Clinical Features and Natural History of Paediatric Patients with Ulcerative Proctitis: A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN

Popis výsledku anglicky

BACKGROUND AND AIMS: Ulcerative proctitis (UP) is an uncommon presentation in paediatric patients with ulcerative colitis. We aimed to characterize the clinical features and natural history of UP in children, and identify predictors of poor outcomes. METHODS: Retrospective study involving 37 sites affiliated with the IBD Porto Group of ESPGHAN. Data were collected from patients aged&lt;18 years diagnosed with UP between 01/01/2016-31/12/2020. RESULTS: We identified 196 patients with UP (median age at diagnosis 14.6 [IQR 12.5-16.0] years), with a median follow-up of 2.7 (IQR 1.7-3.8) years. The most common presenting symptoms were bloody stools (95%), abdominal pain (61%) and diarrhea )47%). At diagnosis, the median paediatric ulcerative colitis activity index (PUCAI) score was 25 (IQR 20-35), but most patients exhibited moderate-severe endoscopic inflammation. By the end-of-induction, 5-aminosalicylic acid administration orally, topically or both resulted in clinical remission rates of 48%, 48% and 73%, respectively. The rates of treatment escalation to biologics at 1, 3 and 5 years were 10%, 22% and 43%, respectively. In multivariate analysis, the PUCAI score at diagnosis was significantly associated with initiation of systemic steroids, or biologics, and subsequent acute severe colitis events and IBD-associated admission, with a score&gt;=35 providing increased risk for poor outcomes. By the end of follow-up, 3.1% of patients underwent colectomy. Patients with proximal disease progression (48%) had significantly higher rates of cecal patch at diagnosis and higher PUCAI score by end-of-induction, compared to those without progression. CONCLUSION: Paediatric patients with UP exhibit high rates of treatment escalation and proximal disease extension.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Crohn&apos;s and Colitis

ISSN

1873-9946

e-ISSN

1876-4479

Svazek periodika

17

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

1939-1948

Kód UT WoS článku

001186264900001

EID výsledku v databázi Scopus

2-s2.0-85182888827