Extended Ischemic Time (> 15 Hours) Using Controlled Hypothermic Storage in Lung Transplantation: A Multicenter Experience

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F24%3A10477330" target="_blank" >RIV/00064203:_____/24:10477330 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10477330 RIV/00216208:11130/24:10477330

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1iHRbcERDJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1iHRbcERDJ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.healun.2024.02.006" target="_blank" >10.1016/j.healun.2024.02.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Extended Ischemic Time (> 15 Hours) Using Controlled Hypothermic Storage in Lung Transplantation: A Multicenter Experience

Popis výsledku v původním jazyce

Static ice storage has long been the standard-of-care for lung preservation, although freezing injury limits ischemic time (IT). Controlled hypothermic storage (CHS) at elevated temperature could safely extend IT. This retrospective analysis assesses feasibility and safety of CHS with IT&gt;15h. Three lung transplant (LuTx) centers (April-October 2023) included demographics, storage details, IT and short-term outcome from 13 LuTx recipients (8 male, 59 years old). Donor lungs were preserved in a portable CHS-device at 7(5-9.3)°C. Indication was overnight bridging and/or long-distance transport. IT of second-implanted lung was 17.3(15.1-22)h. LuTx were successful, 4/13 exhibited primary graft dysfunction grade 3 within 72h and 0/13 at 72h. Post-LuTx mechanical ventilation was 29(7-442)h. Intensive care unit stay was 9(5-28) and hospital stay 30(16-90) days. Four patients needed post-operative extracorporeal membrane oxygenation (ECMO). One patient died (day seven) following malpositioning of an ECMO cannula. This multi-center experience demonstrates the possibility of safely extending IT&gt;15h by CHS.

Název v anglickém jazyce

Extended Ischemic Time (> 15 Hours) Using Controlled Hypothermic Storage in Lung Transplantation: A Multicenter Experience

Popis výsledku anglicky

Static ice storage has long been the standard-of-care for lung preservation, although freezing injury limits ischemic time (IT). Controlled hypothermic storage (CHS) at elevated temperature could safely extend IT. This retrospective analysis assesses feasibility and safety of CHS with IT&gt;15h. Three lung transplant (LuTx) centers (April-October 2023) included demographics, storage details, IT and short-term outcome from 13 LuTx recipients (8 male, 59 years old). Donor lungs were preserved in a portable CHS-device at 7(5-9.3)°C. Indication was overnight bridging and/or long-distance transport. IT of second-implanted lung was 17.3(15.1-22)h. LuTx were successful, 4/13 exhibited primary graft dysfunction grade 3 within 72h and 0/13 at 72h. Post-LuTx mechanical ventilation was 29(7-442)h. Intensive care unit stay was 9(5-28) and hospital stay 30(16-90) days. Four patients needed post-operative extracorporeal membrane oxygenation (ECMO). One patient died (day seven) following malpositioning of an ECMO cannula. This multi-center experience demonstrates the possibility of safely extending IT&gt;15h by CHS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Heart and Lung Transplantation

ISSN

1053-2498

e-ISSN

1557-3117

Svazek periodika

43

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

999-1004

Kód UT WoS článku

001244535600001

EID výsledku v databázi Scopus

2-s2.0-85187323631