Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10487405" target="_blank" >RIV/00064203:_____/25:10487405 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10487405

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Xe5Axv5pl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Xe5Axv5pl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cmi.2024.11.007" target="_blank" >10.1016/j.cmi.2024.11.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study

Popis výsledku v původním jazyce

OBJECTIVES: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the ICU. The aim of this study was to determine the incidence of PA ICU pneumonia (PAIP) and to quantify its independent association with PA colonisation at different body sites. METHODS: Adult patients on mechanical ventilation at ICU admission were prospectively enrolled across 30 European ICUs. PA colonisation in the perianal area and in the lower respiratory tract were assessed within 72 hours after ICU admission and twice weekly until ICU discharge. PAIP development was evaluated daily. Competing risk models with colonisation as a time-varying exposure and ICU death and discharge as competing events were fitted and adjusted for confounders to investigate the association between PA carriage and PAIP. RESULTS: 1971 subjects were enrolled. The colonisation prevalence with P. aeruginosa in the first 72 hours of ICU admission was 10.4% (179 perianal, 51 respiratory), while the acquisition incidence during the ICU stay was 7.0% (158 perianal, 47 respiratory). Of the 43 (1.8%) patients who developed PAIP, 11 (25.6%) were PA colonised on admission and 9 (20.9%) acquired colonisation prior to PAIP onset. Both perianal (adjusted sub distribution hazard ratio [aSHR] 4.4, 95%CI 1.7-11.6) and respiratory colonisation (aSHR 4.6, 95%CI 1.9-11.1) were independently associated with PAIP development. CONCLUSIONS: PAIP incidence was higher in PA colonised vs non-colonised patients. Both colonisation of the rectum and of the respiratory tract were associated with development of PAIP. The increased risk of P. aeruginosa colonisation for subsequent infection provides an opportunity for targeted preventive interventions.

Název v anglickém jazyce

Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study

Popis výsledku anglicky

OBJECTIVES: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the ICU. The aim of this study was to determine the incidence of PA ICU pneumonia (PAIP) and to quantify its independent association with PA colonisation at different body sites. METHODS: Adult patients on mechanical ventilation at ICU admission were prospectively enrolled across 30 European ICUs. PA colonisation in the perianal area and in the lower respiratory tract were assessed within 72 hours after ICU admission and twice weekly until ICU discharge. PAIP development was evaluated daily. Competing risk models with colonisation as a time-varying exposure and ICU death and discharge as competing events were fitted and adjusted for confounders to investigate the association between PA carriage and PAIP. RESULTS: 1971 subjects were enrolled. The colonisation prevalence with P. aeruginosa in the first 72 hours of ICU admission was 10.4% (179 perianal, 51 respiratory), while the acquisition incidence during the ICU stay was 7.0% (158 perianal, 47 respiratory). Of the 43 (1.8%) patients who developed PAIP, 11 (25.6%) were PA colonised on admission and 9 (20.9%) acquired colonisation prior to PAIP onset. Both perianal (adjusted sub distribution hazard ratio [aSHR] 4.4, 95%CI 1.7-11.6) and respiratory colonisation (aSHR 4.6, 95%CI 1.9-11.1) were independently associated with PAIP development. CONCLUSIONS: PAIP incidence was higher in PA colonised vs non-colonised patients. Both colonisation of the rectum and of the respiratory tract were associated with development of PAIP. The increased risk of P. aeruginosa colonisation for subsequent infection provides an opportunity for targeted preventive interventions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Microbiology and Infection

ISSN

1198-743X

e-ISSN

1469-0691

Svazek periodika

31

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

433-440

Kód UT WoS článku

001435228300001

EID výsledku v databázi Scopus

2-s2.0-85211967558