Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10503387" target="_blank" >RIV/00064203:_____/25:10503387 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10503387

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v5YhrSYNLZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v5YhrSYNLZ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10815-025-03624-0" target="_blank" >10.1007/s10815-025-03624-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?

Popis výsledku v původním jazyce

Purpose: Assisted reproductive technology (ART) has been associated with increased risks of congenital anomalies and preterm birth. However, its role in influencing the complexity of specific malformations, such as esophageal atresia (EA), remains unclear. This study aimed to assess whether ART impacts the phenotypic complexity of EA, including associated anomalies and VACTERL (vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies) association. Methods: Data from 374 EA patients enrolled in the European Pediatric Surgeons&apos; Association (EUPSA) Esophageal Atresia Registry were analyzed. Patients were grouped based on mode of conception (28 ART and 346 natural conception) and compared for demographics, gestational age, birth weight, associated malformations, VACTERL association, and genetic disorders. Results: Gestational age and birth weight were comparable between groups (36.5 +- 3.3 vs. 36.4 +- 3.3 weeks, p = 0.42; 2412.3 +- 761.6 g vs. 2601.3 +- 744.3 g, p = 0.24). Maternal age was significantly higher in the ART group. The prevalence of cardiac, gastrointestinal, renal, musculoskeletal, and vertebral anomalies did not differ significantly. All cardiac anomalies in ART patients were minor. VACTERL association rates (25.0% vs. 18.5%, p = 0.398) and genetic disorder prevalence (7.1% vs. 4.9%, p = 0.605) were comparable. Conclusions: ART does not appear to increase the complexity of EA in terms of associated malformations, VACTERL spectrum disorders, or genetic abnormalities. Further studies with larger cohorts and detailed ART subtype data are warranted to confirm these findings.

Název v anglickém jazyce

Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?

Popis výsledku anglicky

Purpose: Assisted reproductive technology (ART) has been associated with increased risks of congenital anomalies and preterm birth. However, its role in influencing the complexity of specific malformations, such as esophageal atresia (EA), remains unclear. This study aimed to assess whether ART impacts the phenotypic complexity of EA, including associated anomalies and VACTERL (vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies) association. Methods: Data from 374 EA patients enrolled in the European Pediatric Surgeons&apos; Association (EUPSA) Esophageal Atresia Registry were analyzed. Patients were grouped based on mode of conception (28 ART and 346 natural conception) and compared for demographics, gestational age, birth weight, associated malformations, VACTERL association, and genetic disorders. Results: Gestational age and birth weight were comparable between groups (36.5 +- 3.3 vs. 36.4 +- 3.3 weeks, p = 0.42; 2412.3 +- 761.6 g vs. 2601.3 +- 744.3 g, p = 0.24). Maternal age was significantly higher in the ART group. The prevalence of cardiac, gastrointestinal, renal, musculoskeletal, and vertebral anomalies did not differ significantly. All cardiac anomalies in ART patients were minor. VACTERL association rates (25.0% vs. 18.5%, p = 0.398) and genetic disorder prevalence (7.1% vs. 4.9%, p = 0.605) were comparable. Conclusions: ART does not appear to increase the complexity of EA in terms of associated malformations, VACTERL spectrum disorders, or genetic abnormalities. Further studies with larger cohorts and detailed ART subtype data are warranted to confirm these findings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Assisted Reproduction and Genetics

ISSN

1058-0468

e-ISSN

1573-7330

Svazek periodika

42

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

3429-3434

Kód UT WoS článku

001568703600001

EID výsledku v databázi Scopus

2-s2.0-105016810122