T, B, and NK cells versus the primary immunodeficiency orientation tube for diagnostic screening of IEIs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10504253" target="_blank" >RIV/00064203:_____/25:10504253 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10504253

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7S-txiWtpn" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7S-txiWtpn</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaci.2025.09.021" target="_blank" >10.1016/j.jaci.2025.09.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

T, B, and NK cells versus the primary immunodeficiency orientation tube for diagnostic screening of IEIs

Popis výsledku v původním jazyce

Flow cytometric quantification of the major populations of peripheral blood lymphocytes is key in the diagnostic screening of inborn errors of immunity (IEIs). However, no consensus exists about the level of detail required at the lymphocyte population level. Analysis of total, CD4 and CD8 PB T-cell levels, and total B- and natural killer (NK) cell levels through combined assessment of CD3, CD4, CD8, CD19, and CD56 is broadly recommended for the screening of severe combined immunodeficiency (SCID), nonsevere combined immunodeficiency (CID), predominantly antibody deficiency (PAD), and diseases of immune dysregulation (DIDs), and it is used at many reference centers.4 However, several guidelines suggest that more in-depth dissection of the maturation compartments (eg, naive and memory) of TCD4, TCD8, and B cells (eg, immunoglobulin heavy chain [IgH]-unswitched vs IgH-switched memory B cells [MBCs] and plasma cells [PCs]) is needed for more sensitive and accurate IEI diagnosis.

Název v anglickém jazyce

T, B, and NK cells versus the primary immunodeficiency orientation tube for diagnostic screening of IEIs

Popis výsledku anglicky

Flow cytometric quantification of the major populations of peripheral blood lymphocytes is key in the diagnostic screening of inborn errors of immunity (IEIs). However, no consensus exists about the level of detail required at the lymphocyte population level. Analysis of total, CD4 and CD8 PB T-cell levels, and total B- and natural killer (NK) cell levels through combined assessment of CD3, CD4, CD8, CD19, and CD56 is broadly recommended for the screening of severe combined immunodeficiency (SCID), nonsevere combined immunodeficiency (CID), predominantly antibody deficiency (PAD), and diseases of immune dysregulation (DIDs), and it is used at many reference centers.4 However, several guidelines suggest that more in-depth dissection of the maturation compartments (eg, naive and memory) of TCD4, TCD8, and B cells (eg, immunoglobulin heavy chain [IgH]-unswitched vs IgH-switched memory B cells [MBCs] and plasma cells [PCs]) is needed for more sensitive and accurate IEI diagnosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Allergy and Clinical Immunology

ISSN

0091-6749

e-ISSN

1097-6825

Svazek periodika

156

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

1772-1775

Kód UT WoS článku

001638192200001

EID výsledku v databázi Scopus

2-s2.0-105022472011