Arrhythmogenic Toxicity in Radiotherapy: Cardiac Conduction System as an Emerging Organ at Risk

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10504277" target="_blank" >RIV/00064203:_____/25:10504277 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10504277

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9J80EITHxq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9J80EITHxq</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-025-00356-6" target="_blank" >10.1007/s44411-025-00356-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Arrhythmogenic Toxicity in Radiotherapy: Cardiac Conduction System as an Emerging Organ at Risk

Popis výsledku v původním jazyce

BackgroundCardiovascular disease is the most common non-oncologic cause of death in patients treated with radiotherapy in thoracic region. Radiation-induced heart disease (RIHD) includes a range of structural and functional complications, among which arrhythmogenic toxicity-conduction disorders and arrhythmias-has gained increasing attention. The cardiac conduction system is not routinely delineated as an organ at risk (OAR), nor are the surrounding structures such as the pulmonary veins, which represent a key pathophysiological site in the development of supraventricular arrhythmias. Traditional parameters like mean heart dose (MHD) may not adequately reflect regional radiosensitivity, particularly in anatomically distinct substructures located at the base of the heart, such as the sinoatrial (SA) and atrioventricular (AV) nodes.AimThis review summarizes current evidence on the effects of radiotherapy on the cardiac conduction system and highlights emerging data on its role in arrhythmogenic toxicity.ConclusionRadiation-induced arrhythmias can occur early after treatment. The heart&apos;s heterogeneous radiosensitivity challenges the use of mean heart dose (MHD) as a predictive metric. Recent studies suggest that cardiac substructures, especially the base of the heart, may be critical regions. A shift toward substructure-specific dosimetry is needed. Recently, arrhythmogenic cardiotoxicity has attracted greater interest in lung cancer, as improvements in overall survival with immunotherapy and targeted agents have increased the relevance of long-term treatment-related toxicities, including radiation-induced arrhythmias.

Název v anglickém jazyce

Arrhythmogenic Toxicity in Radiotherapy: Cardiac Conduction System as an Emerging Organ at Risk

Popis výsledku anglicky

BackgroundCardiovascular disease is the most common non-oncologic cause of death in patients treated with radiotherapy in thoracic region. Radiation-induced heart disease (RIHD) includes a range of structural and functional complications, among which arrhythmogenic toxicity-conduction disorders and arrhythmias-has gained increasing attention. The cardiac conduction system is not routinely delineated as an organ at risk (OAR), nor are the surrounding structures such as the pulmonary veins, which represent a key pathophysiological site in the development of supraventricular arrhythmias. Traditional parameters like mean heart dose (MHD) may not adequately reflect regional radiosensitivity, particularly in anatomically distinct substructures located at the base of the heart, such as the sinoatrial (SA) and atrioventricular (AV) nodes.AimThis review summarizes current evidence on the effects of radiotherapy on the cardiac conduction system and highlights emerging data on its role in arrhythmogenic toxicity.ConclusionRadiation-induced arrhythmias can occur early after treatment. The heart&apos;s heterogeneous radiosensitivity challenges the use of mean heart dose (MHD) as a predictive metric. Recent studies suggest that cardiac substructures, especially the base of the heart, may be critical regions. A shift toward substructure-specific dosimetry is needed. Recently, arrhythmogenic cardiotoxicity has attracted greater interest in lung cancer, as improvements in overall survival with immunotherapy and targeted agents have increased the relevance of long-term treatment-related toxicities, including radiation-induced arrhythmias.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Svazek periodika

126

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

13

Strana od-do

3306-3318

Kód UT WoS článku

001591965200001

EID výsledku v databázi Scopus

2-s2.0-105018778529