Second Primary Cancer After Bladder Cancer: A Comprehensive Analysis of a National Cancer Registry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10505946" target="_blank" >RIV/00064203:_____/25:10505946 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143743 RIV/00216208:11130/25:10505946

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=evRJvmi3aI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=evRJvmi3aI</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cam4.71427" target="_blank" >10.1002/cam4.71427</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Second Primary Cancer After Bladder Cancer: A Comprehensive Analysis of a National Cancer Registry

Popis výsledku v původním jazyce

BACKGROUND: Bladder cancer (BC) is one of the most common cancers and many patients will experience long-term survival. Non-urothelial second primary cancers (SPC) relatively frequently occur in the population of BC survivors. METHODS: Czech National Cancer Registry was the principal data source for this study. The risk of development of non-urothelial SPC after BC was assessed by the standardized incidence ratio (SIR). The standardized mortality ratio (SMR) was utilized to determine the risk of death from SPC following BC. RESULTS: Of the total of 61,314 patients with BC, a cohort of 12,645 survivors diagnosed with a SPC were analyzed. Compared to the general population, the SIR of neoplasia was significantly increased in BC survivors, with a SIR of 1.75 (95% confidence interval [CI] 1.72-1.78) for all cancers, especially during the first 5 years after BC diagnosis. The SMR was increased in BC survivors (1.25; 95% CI 1.21-1.29) for all cancers. Lung cancer frequently occurred as a SPC and was associated with high mortality in BC survivors. BC survivors also had a higher risk of laryngeal cancer and other cancers known to be strongly associated with smoking, but also of soft tissue tumors, colorectal cancer, chronic lymphocytic leukemia, and thyroid cancer. CONCLUSIONS: The present large registry-based study shows that BC survivors have a significantly higher risk of being diagnosed with another primary cancer compared to the general population, especially during the first 5 years after BC diagnosis. In addition to smoking-related cancers, increased incidence of some cancers not known to be associated with smoking was observed.

Název v anglickém jazyce

Second Primary Cancer After Bladder Cancer: A Comprehensive Analysis of a National Cancer Registry

Popis výsledku anglicky

BACKGROUND: Bladder cancer (BC) is one of the most common cancers and many patients will experience long-term survival. Non-urothelial second primary cancers (SPC) relatively frequently occur in the population of BC survivors. METHODS: Czech National Cancer Registry was the principal data source for this study. The risk of development of non-urothelial SPC after BC was assessed by the standardized incidence ratio (SIR). The standardized mortality ratio (SMR) was utilized to determine the risk of death from SPC following BC. RESULTS: Of the total of 61,314 patients with BC, a cohort of 12,645 survivors diagnosed with a SPC were analyzed. Compared to the general population, the SIR of neoplasia was significantly increased in BC survivors, with a SIR of 1.75 (95% confidence interval [CI] 1.72-1.78) for all cancers, especially during the first 5 years after BC diagnosis. The SMR was increased in BC survivors (1.25; 95% CI 1.21-1.29) for all cancers. Lung cancer frequently occurred as a SPC and was associated with high mortality in BC survivors. BC survivors also had a higher risk of laryngeal cancer and other cancers known to be strongly associated with smoking, but also of soft tissue tumors, colorectal cancer, chronic lymphocytic leukemia, and thyroid cancer. CONCLUSIONS: The present large registry-based study shows that BC survivors have a significantly higher risk of being diagnosed with another primary cancer compared to the general population, especially during the first 5 years after BC diagnosis. In addition to smoking-related cancers, increased incidence of some cancers not known to be associated with smoking was observed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Medicine

ISSN

2045-7634

e-ISSN

2045-7634

Svazek periodika

14

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

e71427

Kód UT WoS článku

001627680300001

EID výsledku v databázi Scopus

2-s2.0-105023453672