Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F14%3A%230000434" target="_blank" >RIV/00064211:_____/14:#0000434 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61388955:_____/14:00434380 RIV/00216208:11110/14:10288452 RIV/00216208:11310/14:10288452 RIV/00064165:_____/14:10288452
Výsledek na webu
<a href="http://iopscience.iop.org/article/10.1088/1752-7155/8/3/037109/meta;jsessionid=312B2D03C62CC991C65210BE718254B9.c4.iopscience.cld.iop.org" target="_blank" >http://iopscience.iop.org/article/10.1088/1752-7155/8/3/037109/meta;jsessionid=312B2D03C62CC991C65210BE718254B9.c4.iopscience.cld.iop.org</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1752-7155/8/3/037109" target="_blank" >10.1088/1752-7155/8/3/037109</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease
Popis výsledku v původním jazyce
The objective of this experimental study was to discover volatile metabolites present in exhaled breath that could be used as biomarkers of gastro-esophageal reflux disease, GERD, one of the most common causes of chronic cough. An in vitro model based on pork tissue samples exposed to a challenge by artificial gastric fluid was used to identify specific volatile compounds to be chosen for quantification in directly exhaled breath of GERD patients and controls using selected ion flow tube mass spectrometry, SIFT-MS. GC/MS analyses of the headspace of this in vitro model indicated that the only volatile compound significantly increased was acetic acid. End expiratory concentration of acetic acid measured by SIFT-MS in mouth exhaled breath of 22 GERD patients (median 85 ppbv) was found to be significantly higher than that in breath of a control group (median 48 ppbv). Breath acetic acid may be useful for non-invasive diagnostics of GERD and other conditions resulting in the lowering of pH of the lining of the airways.
Název v anglickém jazyce
Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease
Popis výsledku anglicky
The objective of this experimental study was to discover volatile metabolites present in exhaled breath that could be used as biomarkers of gastro-esophageal reflux disease, GERD, one of the most common causes of chronic cough. An in vitro model based on pork tissue samples exposed to a challenge by artificial gastric fluid was used to identify specific volatile compounds to be chosen for quantification in directly exhaled breath of GERD patients and controls using selected ion flow tube mass spectrometry, SIFT-MS. GC/MS analyses of the headspace of this in vitro model indicated that the only volatile compound significantly increased was acetic acid. End expiratory concentration of acetic acid measured by SIFT-MS in mouth exhaled breath of 22 GERD patients (median 85 ppbv) was found to be significantly higher than that in breath of a control group (median 48 ppbv). Breath acetic acid may be useful for non-invasive diagnostics of GERD and other conditions resulting in the lowering of pH of the lining of the airways.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FC - Pneumologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
JOURNAL OF BREATH RESEARCH
ISSN
1752-7155
e-ISSN
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Svazek periodika
8
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
nestrankovano
Kód UT WoS článku
000341774500014
EID výsledku v databázi Scopus
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