Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F15%3A%230000412" target="_blank" >RIV/00064211:_____/15:#0000412 - isvavai.cz</a>

Výsledek na webu

<a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9527963&fileId=S0950268814001253" target="_blank" >http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9527963&fileId=S0950268814001253</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0950268814001253" target="_blank" >10.1017/S0950268814001253</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients

Popis výsledku v původním jazyce

To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV-infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909 x 3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosedin 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12 x 6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3 x 3-fold) and natural killer cells (4 x 3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40 x 2 vs. 3 x 4/1000 person-years) between monitored periods was seen. In the cART era, To

Název v anglickém jazyce

Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients

Popis výsledku anglicky

To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV-infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909 x 3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosedin 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12 x 6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3 x 3-fold) and natural killer cells (4 x 3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40 x 2 vs. 3 x 4/1000 person-years) between monitored periods was seen. In the cART era, To

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11429" target="_blank" >NT11429: Ovlivnění imunitního a klinického stavu HIV-pozitivních pacientů bezpříznakovou infekcí parazitickým prvokem Toxoplasma gondii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epidemiology and Infection

ISSN

1469-4409

e-ISSN

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Svazek periodika

143

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

600-607

Kód UT WoS článku

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EID výsledku v databázi Scopus

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