The effects of intrapartum synthetic oxytocin on maternal postpartum mood: findings from a prospective observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F18%3AM0000104" target="_blank" >RIV/00064211:_____/18:M0000104 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10380499 RIV/00216208:11210/19:10380499 RIV/00216208:11140/19:10380499 RIV/00023752:_____/19:43919555 a 2 dalších

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pubmed/30306269/" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/30306269/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00737-018-0913-3" target="_blank" >10.1007/s00737-018-0913-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effects of intrapartum synthetic oxytocin on maternal postpartum mood: findings from a prospective observational study

Popis výsledku v původním jazyce

Postpartum depression (PPD) affects up to 19% of all mothers, with detrimental effects on both mother and child. The antidepressant and anxiolytic effects of plasma oxytocin are well-documented, but it is still disputable whether synthetic oxytocin (synOT) may protect women against postpartum mood alterations. The current study examined the association between synOT intrapartum and maternal mood postpartum using a prospective design. Two hundred sixty women were screened for depressive symptoms in the last trimester of pregnancy and then again 6 weeks and 9 months postpartum using the Edinburgh Postnatal Depression Scale. They also completed Maternity Blues Questionnaire in the first postpartum week. The data concerning the intrapartum interventions and health status of the newborn were extracted from the medical records. Cox proportional hazards regression adjusted for a history of depression, mode of delivery, and childbirth experience showed that synOT predicted a significantly lower risk of PPD (HR = 0.65, 95% CI 0.45-0.95, p = 0.025). The risk factors for PPD included a history of depression (HR = 3.20, 95% CI 2.33-4.40, p < 0.001) and negative childbirth experience (HR = 1.39, 95% CI 1.01-1.90, p = 0.040). Logistic regression adjusted for the same covariates found no significant effect of synOT on maternity blues (OR = 0.64, 95% CI 0.31-1.32, p = 0.23). While synOT administered intrapartum does not affect maternal mood immediately, it may come to effect some weeks after childbirth to protect mothers from developing PPD symptoms.

Název v anglickém jazyce

The effects of intrapartum synthetic oxytocin on maternal postpartum mood: findings from a prospective observational study

Popis výsledku anglicky

Postpartum depression (PPD) affects up to 19% of all mothers, with detrimental effects on both mother and child. The antidepressant and anxiolytic effects of plasma oxytocin are well-documented, but it is still disputable whether synthetic oxytocin (synOT) may protect women against postpartum mood alterations. The current study examined the association between synOT intrapartum and maternal mood postpartum using a prospective design. Two hundred sixty women were screened for depressive symptoms in the last trimester of pregnancy and then again 6 weeks and 9 months postpartum using the Edinburgh Postnatal Depression Scale. They also completed Maternity Blues Questionnaire in the first postpartum week. The data concerning the intrapartum interventions and health status of the newborn were extracted from the medical records. Cox proportional hazards regression adjusted for a history of depression, mode of delivery, and childbirth experience showed that synOT predicted a significantly lower risk of PPD (HR = 0.65, 95% CI 0.45-0.95, p = 0.025). The risk factors for PPD included a history of depression (HR = 3.20, 95% CI 2.33-4.40, p < 0.001) and negative childbirth experience (HR = 1.39, 95% CI 1.01-1.90, p = 0.040). Logistic regression adjusted for the same covariates found no significant effect of synOT on maternity blues (OR = 0.64, 95% CI 0.31-1.32, p = 0.23). While synOT administered intrapartum does not affect maternal mood immediately, it may come to effect some weeks after childbirth to protect mothers from developing PPD symptoms.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

<a href="/cs/project/GA17-10464S" target="_blank" >GA17-10464S: Perinatální rizikové faktory, mateřské kompetence a psychický vývoj dítěte – prospektivní studie od prenatálního období do předškolního věku</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of women's mental health

ISSN

1434-1816

e-ISSN

1435-1102

Svazek periodika

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Číslo periodika v rámci svazku

2018 Oct 10

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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