Androgenetic alopecia may be associated with weaker COVID-19 T-cell immune response: An insight into a potential COVID-19 vaccine booster

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F21%3AW0000038" target="_blank" >RIV/00064211:_____/21:W0000038 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/21:10426325

Výsledek na webu

<a href="https://oadoi.org/10.1016/j.mehy.2020.110439" target="_blank" >https://oadoi.org/10.1016/j.mehy.2020.110439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mehy.2020.110439" target="_blank" >10.1016/j.mehy.2020.110439</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Androgenetic alopecia may be associated with weaker COVID-19 T-cell immune response: An insight into a potential COVID-19 vaccine booster

Popis výsledku v původním jazyce

The COVID-19 pandemic has had a devastating impact on humans, society, and the global economy. Returning to pre-pandemic activity hinges on the development of robust immunization against SARS-CoV-2. Successful immunization through vaccination or post-exposure to SARS-CoV-2 largely depends on the adaptive immune response. In clinical trials of COVID-19 vaccines, detection of SARS-CoV-2 specific IgG antibodies is an accepted endpoint for establishing immune response. Unfortunately, several studies have reported rapid decline in IgG titters following both SARS-CoV-2 infection or vaccination [1]. Our recent work has explored the influence of the androgen receptor (AR) on COVID-19 disease severity [2]. We have elucidated that androgen sensitive phenotypes, e.g., androgenetic alopecia (AGA), are associated with increased disease severity [3]. Here we propose that the dependence of SARS-CoV-2 on the AR may extend to the immune response and might be an important consideration for vaccine development.

Název v anglickém jazyce

Androgenetic alopecia may be associated with weaker COVID-19 T-cell immune response: An insight into a potential COVID-19 vaccine booster

Popis výsledku anglicky

The COVID-19 pandemic has had a devastating impact on humans, society, and the global economy. Returning to pre-pandemic activity hinges on the development of robust immunization against SARS-CoV-2. Successful immunization through vaccination or post-exposure to SARS-CoV-2 largely depends on the adaptive immune response. In clinical trials of COVID-19 vaccines, detection of SARS-CoV-2 specific IgG antibodies is an accepted endpoint for establishing immune response. Unfortunately, several studies have reported rapid decline in IgG titters following both SARS-CoV-2 infection or vaccination [1]. Our recent work has explored the influence of the androgen receptor (AR) on COVID-19 disease severity [2]. We have elucidated that androgen sensitive phenotypes, e.g., androgenetic alopecia (AGA), are associated with increased disease severity [3]. Here we propose that the dependence of SARS-CoV-2 on the AR may extend to the immune response and might be an important consideration for vaccine development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30502 - Other medical science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MEDICAL HYPOTHESES

ISSN

0306-9877

e-ISSN

1532-2777

Svazek periodika

146

Číslo periodika v rámci svazku

JAN

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

-

Kód UT WoS článku

000614812300015

EID výsledku v databázi Scopus

2-s2.0-85097791083