Impact of comorbidity scores and lifestyle factors in curative radiotherapy in laryngeal cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F23%3AW0000024" target="_blank" >RIV/00064211:_____/23:W0000024 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10465275 RIV/00064190:_____/23:10001153

Výsledek na webu

<a href="https://oadoi.org/10.1007/s00066-023-02072-y" target="_blank" >https://oadoi.org/10.1007/s00066-023-02072-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00066-023-02072-y" target="_blank" >10.1007/s00066-023-02072-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of comorbidity scores and lifestyle factors in curative radiotherapy in laryngeal cancer

Popis výsledku v původním jazyce

PurposeThe principal goal of treatment of laryngeal cancer is to eliminate a tumour while preserving laryngeal function with radio(chemo)therapy being the mainstay of treatment. The aim of this report is to present the influence of comorbidities and lifestyle factors on treatment outcomes in our cohort of patients.MethodsDuring the period 2009-2018, curative radio(chemo)therapy for laryngeal cancer was performed on 189 patients.ResultsThe median OS was 50.8 months, with a mean PFS of 96.5 months, mean LC of 101.4 months and a median follow-up of 38.1 months. Acute and late treatment toxicity grade 3-4 was observed in 39.2% patients and 10.1% patients, respectively. A significant effect on overall survival was confirmed for the baseline PS (performance status), severity of weight loss, baseline haemoglobin values, history of alcohol abuse, marital status and comorbidities according to the Charlson Comorbidity Index, as well as the ACE-27 and ASA scores.ConclusionsIn our cohort of patients treated with radio(chemo)therapy for laryngeal cancer, we found good therapeutic results and an acceptable side-effect profile. Statistically significant predictors of overall survival were the baseline PS, weight loss, anaemia, associated comorbidities, history of alcohol abuse and marital status.

Název v anglickém jazyce

Impact of comorbidity scores and lifestyle factors in curative radiotherapy in laryngeal cancer

Popis výsledku anglicky

PurposeThe principal goal of treatment of laryngeal cancer is to eliminate a tumour while preserving laryngeal function with radio(chemo)therapy being the mainstay of treatment. The aim of this report is to present the influence of comorbidities and lifestyle factors on treatment outcomes in our cohort of patients.MethodsDuring the period 2009-2018, curative radio(chemo)therapy for laryngeal cancer was performed on 189 patients.ResultsThe median OS was 50.8 months, with a mean PFS of 96.5 months, mean LC of 101.4 months and a median follow-up of 38.1 months. Acute and late treatment toxicity grade 3-4 was observed in 39.2% patients and 10.1% patients, respectively. A significant effect on overall survival was confirmed for the baseline PS (performance status), severity of weight loss, baseline haemoglobin values, history of alcohol abuse, marital status and comorbidities according to the Charlson Comorbidity Index, as well as the ACE-27 and ASA scores.ConclusionsIn our cohort of patients treated with radio(chemo)therapy for laryngeal cancer, we found good therapeutic results and an acceptable side-effect profile. Statistically significant predictors of overall survival were the baseline PS, weight loss, anaemia, associated comorbidities, history of alcohol abuse and marital status.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

STRAHLENTHERAPIE UND ONKOLOGIE

ISSN

0179-7158

e-ISSN

1439-099X

Svazek periodika

199

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

881-890

Kód UT WoS článku

000970942400002

EID výsledku v databázi Scopus

2-s2.0-85152422043