Tuberculosis transmission and resistance among Ukrainian migrants and its impact on multidrug-resistant tuberculosis dynamics in high-influx host countries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F26%3AW0000087" target="_blank" >RIV/00064211:_____/26:W0000087 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/26:10001439

Výsledek na webu

<a href="https://oadoi.org/10.1186/s12866-026-04874-3" target="_blank" >https://oadoi.org/10.1186/s12866-026-04874-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12866-026-04874-3" target="_blank" >10.1186/s12866-026-04874-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tuberculosis transmission and resistance among Ukrainian migrants and its impact on multidrug-resistant tuberculosis dynamics in high-influx host countries

Popis výsledku v původním jazyce

Background The war in Ukraine triggered unprecedented migration into Central Europe, raising concerns regarding tuberculosis (TB) spread. Methods We conducted a molecular-epidemiological study including all Ukrainian migrants with culture-confirmed TB in Slovakia and the Czech Republic between September 2021 and December 2024 (n = 229), together with all other multidrug-resistant (MDR) TB cases reported in these countries between 2023 and 2024 (n = 28). Whole-genome sequencing (WGS) was performed on cultured Mycobacterium tuberculosis complex (MTBC) isolates, and the resulting data were used for phylogenetic reconstruction, lineage classification, genomic resistance prediction, and cluster analysis. Findings Since the war began in 2022, the share of TB cases from Ukrainian migrants in the Czech Republic rose significantly (P < 0.001), along with an evident increase in total MDR-TB cases. Out of 199 MTBC strains from Ukrainian migrants with good-quality WGS data, 129 (64.8%) were predicted to be susceptible, 25 MDR (12.6%), 8 pre-extensively drug-resistant (pre-XDR; 4%), and 37 (18.6%) had other resistance patterns including bedaquiline/clofazimine monoresistance. Among MDR/pre-XDR strains (n = 59) lineage 2 predominated (63.5%), mainly belonging to the Central Asia clades (45.0%) and the Europe/Russian W148 outbreak clone (52.9%), followed by lineage 4 (28.9%). Cluster analysis (5 allele threshold) identified 10 MDR/pre-XDR TB clusters, each with two isolates. Only one of those clusters included a Ukrainian migrant and non-Ukrainian patient from the host country. Conclusion Migration increased both, the TB and MDR-TB burden especially in the Czech Republic. Transmission of imported MTBC strains from migrants to host populations appears to be limited, but needs to be closely monitered prospectively.

Název v anglickém jazyce

Tuberculosis transmission and resistance among Ukrainian migrants and its impact on multidrug-resistant tuberculosis dynamics in high-influx host countries

Popis výsledku anglicky

Background The war in Ukraine triggered unprecedented migration into Central Europe, raising concerns regarding tuberculosis (TB) spread. Methods We conducted a molecular-epidemiological study including all Ukrainian migrants with culture-confirmed TB in Slovakia and the Czech Republic between September 2021 and December 2024 (n = 229), together with all other multidrug-resistant (MDR) TB cases reported in these countries between 2023 and 2024 (n = 28). Whole-genome sequencing (WGS) was performed on cultured Mycobacterium tuberculosis complex (MTBC) isolates, and the resulting data were used for phylogenetic reconstruction, lineage classification, genomic resistance prediction, and cluster analysis. Findings Since the war began in 2022, the share of TB cases from Ukrainian migrants in the Czech Republic rose significantly (P < 0.001), along with an evident increase in total MDR-TB cases. Out of 199 MTBC strains from Ukrainian migrants with good-quality WGS data, 129 (64.8%) were predicted to be susceptible, 25 MDR (12.6%), 8 pre-extensively drug-resistant (pre-XDR; 4%), and 37 (18.6%) had other resistance patterns including bedaquiline/clofazimine monoresistance. Among MDR/pre-XDR strains (n = 59) lineage 2 predominated (63.5%), mainly belonging to the Central Asia clades (45.0%) and the Europe/Russian W148 outbreak clone (52.9%), followed by lineage 4 (28.9%). Cluster analysis (5 allele threshold) identified 10 MDR/pre-XDR TB clusters, each with two isolates. Only one of those clusters included a Ukrainian migrant and non-Ukrainian patient from the host country. Conclusion Migration increased both, the TB and MDR-TB burden especially in the Czech Republic. Transmission of imported MTBC strains from migrants to host populations appears to be limited, but needs to be closely monitered prospectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2026

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC MICROBIOLOGY

ISSN

1471-2180

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

-

Kód UT WoS článku

001739828400003

EID výsledku v databázi Scopus

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