Treatment with statins and involvement of the peripheral nervous system: results of a prospective clinical and neurophysiological follow-up.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F07%3A%230000102" target="_blank" >RIV/00098892:_____/07:#0000102 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/07:#0000204

Výsledek na webu

<a href="http://biomed.papers.upol.cz" target="_blank" >http://biomed.papers.upol.cz</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Treatment with statins and involvement of the peripheral nervous system: results of a prospective clinical and neurophysiological follow-up.

Popis výsledku v původním jazyce

AIMS: To study the pathological changes in neurophysiological examination of lower-limb peripheral nerves in patients with long-term statin treatment. METHODS: Forty-two patients (23 males, 19 females, mean age 51.9 and 52.3 years) with a definitive diagnosis of combined hyperlipidemia were studied. Other metabolic disorders or chronic ethanol abuse were excluded. Initial examinations included laboratory and neurophysiological measures (peroneal and tibial nerves: MNCV, CMAP, F-wave mean latency; superficial peroneal and sural nerve: SNCV, SNAP). Subsequently, treatment with simvastatin 20mg daily was initiated. Patients were followed for 24 months with examinations at 1, 6, 12 and 24 months after statin treatment initiation. RESULTS: None of the patients reported subjective symptoms typical for polyneuropathy. In laboratory findings, there was no elevation of muscle enzymes. Nevertheless, electrophysiological examination of lower-limb peripheral nerves demonstrated statistically signi

Název v anglickém jazyce

Treatment with statins and involvement of the peripheral nervous system: results of a prospective clinical and neurophysiological follow-up.

Popis výsledku anglicky

AIMS: To study the pathological changes in neurophysiological examination of lower-limb peripheral nerves in patients with long-term statin treatment. METHODS: Forty-two patients (23 males, 19 females, mean age 51.9 and 52.3 years) with a definitive diagnosis of combined hyperlipidemia were studied. Other metabolic disorders or chronic ethanol abuse were excluded. Initial examinations included laboratory and neurophysiological measures (peroneal and tibial nerves: MNCV, CMAP, F-wave mean latency; superficial peroneal and sural nerve: SNCV, SNAP). Subsequently, treatment with simvastatin 20mg daily was initiated. Patients were followed for 24 months with examinations at 1, 6, 12 and 24 months after statin treatment initiation. RESULTS: None of the patients reported subjective symptoms typical for polyneuropathy. In laboratory findings, there was no elevation of muscle enzymes. Nevertheless, electrophysiological examination of lower-limb peripheral nerves demonstrated statistically signi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

151

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

307-310

Kód UT WoS článku

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EID výsledku v databázi Scopus

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