Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F12%3A%230000333" target="_blank" >RIV/00098892:_____/12:#0000333 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia

Popis výsledku v původním jazyce

We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-?) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The medianfollow-up was 82.6 months (range 12.4?212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7?40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase?polymerase chain reaction [?complete? molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4?10) years, while 2 continue with IFN-? and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01?0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite conti

Název v anglickém jazyce

Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia

Popis výsledku anglicky

We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-?) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The medianfollow-up was 82.6 months (range 12.4?212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7?40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase?polymerase chain reaction [?complete? molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4?10) years, while 2 continue with IFN-? and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01?0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite conti

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Interferon & Cytokine Research

ISSN

1079-9907

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

230-234

Kód UT WoS článku

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EID výsledku v databázi Scopus

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