Interaction of anthocyanins with human liver microsomal cytochromes P450

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F13%3A%230000548" target="_blank" >RIV/00098892:_____/13:#0000548 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of anthocyanins with human liver microsomal cytochromes P450

Popis výsledku v původním jazyce

Anthocyanins are pigments present in fruit and vegetables. Antocyanins are glycosides; their aglycones are flavonoids, anthocyanidins (the most common are cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin). In this preliminary report theinhibition of three forms of human liver microsomal CYPs was studied. The CYP3A4 activity was influenced the most being inhibited to about 60% of the original activity by most of the anthocyanins at the highest concentration tested.. Inhibition of CYP2C9 enzyme activity was more prominent with delphinidin-3-glucoside and cyanidin-3-galactoside (down to 60 % of the original activity), CYP1A2 enzyme was inhibited in a small extent. The results indicate that the interactions of anthocyanins with liver CYPenzymes most probably does not pose any harm to human organism based on drug interactions; however, in case of drugs metabolized by CYP3A4, and an ingestion of large amounts of anthocyanins, a limited increase of drug bioavailability may

Název v anglickém jazyce

Interaction of anthocyanins with human liver microsomal cytochromes P450

Popis výsledku anglicky

Anthocyanins are pigments present in fruit and vegetables. Antocyanins are glycosides; their aglycones are flavonoids, anthocyanidins (the most common are cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin). In this preliminary report theinhibition of three forms of human liver microsomal CYPs was studied. The CYP3A4 activity was influenced the most being inhibited to about 60% of the original activity by most of the anthocyanins at the highest concentration tested.. Inhibition of CYP2C9 enzyme activity was more prominent with delphinidin-3-glucoside and cyanidin-3-galactoside (down to 60 % of the original activity), CYP1A2 enzyme was inhibited in a small extent. The results indicate that the interactions of anthocyanins with liver CYPenzymes most probably does not pose any harm to human organism based on drug interactions; however, in case of drugs metabolized by CYP3A4, and an ingestion of large amounts of anthocyanins, a limited increase of drug bioavailability may

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Svazek periodika

157

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

"S56"-"S59"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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