Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000037" target="_blank" >RIV/00098892:_____/16:N0000037 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/16:33160090

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients

Popis výsledku v původním jazyce

A total of 104 patients stabilised after kidney transplantation were converted from maintenance therapy with cyclosporine to treatment with tacrolimus prolonged release (brand name Advagraf) Results of the first six months after the conversion are given. The primary endpoint was change in glomerular filtration rate, which increased after six months by 10 % (p=0,040). In addition a significant decrease of serum creatinine and urea levels, decrease of triglycerides level were noticed. There was an important decline in incidence and severity of gingival hyperplasia and hirsutism. 3 % patients developed a new onset of diabetes mellitus. The switch was very well tolerated, without serious adverse events or acute rejections. Conversion from cyclosporine to tacrolimus prolonged release has shown to be a safe therapeutic alternative with possible benefits for the patient

Název v anglickém jazyce

Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients

Popis výsledku anglicky

A total of 104 patients stabilised after kidney transplantation were converted from maintenance therapy with cyclosporine to treatment with tacrolimus prolonged release (brand name Advagraf) Results of the first six months after the conversion are given. The primary endpoint was change in glomerular filtration rate, which increased after six months by 10 % (p=0,040). In addition a significant decrease of serum creatinine and urea levels, decrease of triglycerides level were noticed. There was an important decline in incidence and severity of gingival hyperplasia and hirsutism. 3 % patients developed a new onset of diabetes mellitus. The switch was very well tolerated, without serious adverse events or acute rejections. Conversion from cyclosporine to tacrolimus prolonged release has shown to be a safe therapeutic alternative with possible benefits for the patient

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

—

Svazek periodika

160

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

407-411

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—