Risk factors for superficial vein thrombosis in patients with primary chronic venous disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000103" target="_blank" >RIV/00098892:_____/16:N0000103 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Risk factors for superficial vein thrombosis in patients with primary chronic venous disease

Popis výsledku v původním jazyce

Background: Primary chronic venous disease (CVD) is associated with an increased risk of superficial vein thrombosis (SVT). While CVD is a predominant factor in SVT, there is a range of additional predisposing factors. The objective was to investigate the association between age, gender, BMI, smoking, oestrogen hormone therapy, family history of venous thromboembolism (VTE) and CEAP clinical classification in patients with CVD and a history of SVT. Patients and methods: In a retrospective observational study on consecutive patients with primary CVD, 641 outpatients were enrolled (152 men, 23.7 %; 489 women, 76.3 %). The prevalence of SVT was evaluated according to age, BMI, smoking, presence of family history of VTE, use of hormone therapy, and clinical class of CVD. Results: Risk of SVT was significantly increased in women (OR 1.68, 95 % CI = 1.02 – 2.76; p = 0.041), older patients (46 – 69 years, OR 1.57, 95% CI = 1.03 – 2.4; p = 0.036, ≥ 70 years, OR 2.93, 95 % CI = 1.5 – 5.76; p = 0.001), smokers (OR 1.69, 95 % CI = 1.1 – 2.58; p = 0.015) and in persons with first-degree siblings diagnosed with VTE (OR 2,28, 95 % CI = 1.28 – 4.05; p = 0.004). The risk was significantly increased in older male smokers (p – 0.042). In women, smoking and oestrogen therapy (p = 0.495) did not increase the risk of SVT even older women or in those with increased BMI. In CVD (C0 – C3), a history of episodes of SVT was found in 103/550 (18.7 %), in chronic venous insufficiency (CVI) in 27/91 (29.7 %). There was a significantly higher prevalence of SVT in patients with CVI (OR 1.70, 95% CI = 1.1 – 2.5; p = 0.016). Conclusions: In patients with primary CVD, SVT was significantly associated with female gender. In men, older age, smoking and positive family history of VTE were relevant SVT risk factors. In women, risk factors were older age, BMI ≥ 25 kg/m2 and positive family history of VTE. Compared with C0 – C3 clinical classes, CVI significantly increases the risk of SVT

Název v anglickém jazyce

Risk factors for superficial vein thrombosis in patients with primary chronic venous disease

Popis výsledku anglicky

Background: Primary chronic venous disease (CVD) is associated with an increased risk of superficial vein thrombosis (SVT). While CVD is a predominant factor in SVT, there is a range of additional predisposing factors. The objective was to investigate the association between age, gender, BMI, smoking, oestrogen hormone therapy, family history of venous thromboembolism (VTE) and CEAP clinical classification in patients with CVD and a history of SVT. Patients and methods: In a retrospective observational study on consecutive patients with primary CVD, 641 outpatients were enrolled (152 men, 23.7 %; 489 women, 76.3 %). The prevalence of SVT was evaluated according to age, BMI, smoking, presence of family history of VTE, use of hormone therapy, and clinical class of CVD. Results: Risk of SVT was significantly increased in women (OR 1.68, 95 % CI = 1.02 – 2.76; p = 0.041), older patients (46 – 69 years, OR 1.57, 95% CI = 1.03 – 2.4; p = 0.036, ≥ 70 years, OR 2.93, 95 % CI = 1.5 – 5.76; p = 0.001), smokers (OR 1.69, 95 % CI = 1.1 – 2.58; p = 0.015) and in persons with first-degree siblings diagnosed with VTE (OR 2,28, 95 % CI = 1.28 – 4.05; p = 0.004). The risk was significantly increased in older male smokers (p – 0.042). In women, smoking and oestrogen therapy (p = 0.495) did not increase the risk of SVT even older women or in those with increased BMI. In CVD (C0 – C3), a history of episodes of SVT was found in 103/550 (18.7 %), in chronic venous insufficiency (CVI) in 27/91 (29.7 %). There was a significantly higher prevalence of SVT in patients with CVI (OR 1.70, 95% CI = 1.1 – 2.5; p = 0.016). Conclusions: In patients with primary CVD, SVT was significantly associated with female gender. In men, older age, smoking and positive family history of VTE were relevant SVT risk factors. In women, risk factors were older age, BMI ≥ 25 kg/m2 and positive family history of VTE. Compared with C0 – C3 clinical classes, CVI significantly increases the risk of SVT

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vasa - European Journal of Vascular Medicine

ISSN

0301-1526

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

63-66

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—