Emergency surgical treatment of complicated acute pancreatitis after kidney transplantation with acute rejection: Case report and literature review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000144" target="_blank" >RIV/00098892:_____/16:N0000144 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/16:33160342

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2049080116300401" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2049080116300401</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amsu.2016.04.022" target="_blank" >10.1016/j.amsu.2016.04.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Emergency surgical treatment of complicated acute pancreatitis after kidney transplantation with acute rejection: Case report and literature review

Popis výsledku v původním jazyce

Introduction:Acute pancreatitis is a rare but frequently fatal complication in patients following kidneytransplantation. Thefirst case of acute pancreatitis in patients following a kidney transplant wasdescribed by Starzl in 1964. The incidence of acute pancreatitis is stated at between 1 and 5%. Themortality rate amongst these patients reaches as high as 50e100%.Presentation of case:Here we present a case of acute pancreatic abscess in a caucasian femaleeshortlyfollowing a kidney transplant complicated by the development of acute rejection, in which immuno-suppressant therapy is a potential etiological agent. Emergency surgical treatment was indicated, whichincluded drainage of the abscesses irrigation of the abdominal cavity. Immunosuppressive medicationwas considered a possible etiological factor, and as a result administration of tacrolimus and myco-phenolate mofetil was discontinued. This was successful and three months later, diagnostic rebiopsy ofthe graft was performed without signs of rejection.Discussion:The etiology of this illness is multifactorial. The clinical manifestation of acute pancreatitis inpatients following kidney transplantation is the same as in the remainder of the population. However, inpatients following transplantation with long-term immunosuppression, it usually manifests a more rapiddevelopment and a more severe, frequently fatal course.Conclusions:With regard to the patient's comorbidities, early surgical therapy was indicatededrainageand closed lavage and immunosuppressive medication as a suspected tobe ethiological factor was dis-continued. This course of treatment led to a complete recovery with preservation of good function of thecadaverous kidney.

Název v anglickém jazyce

Emergency surgical treatment of complicated acute pancreatitis after kidney transplantation with acute rejection: Case report and literature review

Popis výsledku anglicky

Introduction:Acute pancreatitis is a rare but frequently fatal complication in patients following kidneytransplantation. Thefirst case of acute pancreatitis in patients following a kidney transplant wasdescribed by Starzl in 1964. The incidence of acute pancreatitis is stated at between 1 and 5%. Themortality rate amongst these patients reaches as high as 50e100%.Presentation of case:Here we present a case of acute pancreatic abscess in a caucasian femaleeshortlyfollowing a kidney transplant complicated by the development of acute rejection, in which immuno-suppressant therapy is a potential etiological agent. Emergency surgical treatment was indicated, whichincluded drainage of the abscesses irrigation of the abdominal cavity. Immunosuppressive medicationwas considered a possible etiological factor, and as a result administration of tacrolimus and myco-phenolate mofetil was discontinued. This was successful and three months later, diagnostic rebiopsy ofthe graft was performed without signs of rejection.Discussion:The etiology of this illness is multifactorial. The clinical manifestation of acute pancreatitis inpatients following kidney transplantation is the same as in the remainder of the population. However, inpatients following transplantation with long-term immunosuppression, it usually manifests a more rapiddevelopment and a more severe, frequently fatal course.Conclusions:With regard to the patient's comorbidities, early surgical therapy was indicatededrainageand closed lavage and immunosuppressive medication as a suspected tobe ethiological factor was dis-continued. This course of treatment led to a complete recovery with preservation of good function of thecadaverous kidney.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Medicine and Surgery  

ISSN

2049-0801

e-ISSN

2049-0801

Svazek periodika

8

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

14-17

Kód UT WoS článku

000377037300003

EID výsledku v databázi Scopus

2-s2.0-84965067420