Digital cholangioscopy: the diagnostic yield and impact on management of patients with indeterminate biliary stricture

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000031" target="_blank" >RIV/00098892:_____/18:N0000031 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/18:73587895

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Digital cholangioscopy: the diagnostic yield and impact on management of patients with indeterminate biliary stricture

Popis výsledku v původním jazyce

Objectives: Biliary strictures frequently present a diagnostic challenge. The aim of this study was to evaluate the impact of digital single-operator cholangioscopy (DSOC) on subsequent treatment of patients with biliary stricture. Methods: Consecutive patients undergoing DSOC for biliary stricture were enrolled. Gold standard for final diagnosis included histology from surgical resection. In patients without surgery, clinical evaluation methods and repeated imaging studies were used for comparison of DSOC findings and final diagnosis. Patients were followed-up prospectively focusing on subsequent treatment. Results: Among 30 enrolled patients, final diagnosis was malignant in 13 (43 %) and benign in 17 (57 %). The sensitivity and specificity of visual impression in diagnosing malignant stricture were 100% (95% CI: 75 − 100) and 76% (95% CI: 50 − 93), respectively. The sensitivity and specificity for biopsy were 92% (95 % CI: 62 − 100) and 100 % (95 % CI: 78 − 100), respectively. One (3 %) case of complicating cholangitis with fatal outcome occurred. Final treatment included surgery in 7 (23 %), endoscopy in 18 (60 %) and chemotherapy in 3 (10 %) of patients. Conclusions: In this study, favorable operating characteristics of DSOC were confirmed. Absolute negative predictive value of visual impression provided reassurance to patients with benign strictures who avoided unnecessary surgery in 53 %. One (3 %) case of cholangitis with fatal outcome occurred

Název v anglickém jazyce

Digital cholangioscopy: the diagnostic yield and impact on management of patients with indeterminate biliary stricture

Popis výsledku anglicky

Objectives: Biliary strictures frequently present a diagnostic challenge. The aim of this study was to evaluate the impact of digital single-operator cholangioscopy (DSOC) on subsequent treatment of patients with biliary stricture. Methods: Consecutive patients undergoing DSOC for biliary stricture were enrolled. Gold standard for final diagnosis included histology from surgical resection. In patients without surgery, clinical evaluation methods and repeated imaging studies were used for comparison of DSOC findings and final diagnosis. Patients were followed-up prospectively focusing on subsequent treatment. Results: Among 30 enrolled patients, final diagnosis was malignant in 13 (43 %) and benign in 17 (57 %). The sensitivity and specificity of visual impression in diagnosing malignant stricture were 100% (95% CI: 75 − 100) and 76% (95% CI: 50 − 93), respectively. The sensitivity and specificity for biopsy were 92% (95 % CI: 62 − 100) and 100 % (95 % CI: 78 − 100), respectively. One (3 %) case of complicating cholangitis with fatal outcome occurred. Final treatment included surgery in 7 (23 %), endoscopy in 18 (60 %) and chemotherapy in 3 (10 %) of patients. Conclusions: In this study, favorable operating characteristics of DSOC were confirmed. Absolute negative predictive value of visual impression provided reassurance to patients with benign strictures who avoided unnecessary surgery in 53 %. One (3 %) case of cholangitis with fatal outcome occurred

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scandinavian Journal of Gastroenterology

ISSN

0036-5521

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

10-11

Stát vydavatele periodika

NO - Norské království

Počet stran výsledku

4

Strana od-do

1364-1367

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85055480777