Relationship of selected adipokines with markers of vascular damage in patients with type 2 diabetes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000055" target="_blank" >RIV/00098892:_____/18:N0000055 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/18:73589422

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Relationship of selected adipokines with markers of vascular damage in patients with type 2 diabetes

Popis výsledku v původním jazyce

Background: In this study we compared levels of selected adipokines between patients with type 2 diabetes (T2D) and healthy individuals and we determined their relationship with early vascular damage markers. Methods: Seventy-seven subjects: 56 patients with T2D (34 men and 22 women) and 21 healthy controls (8 men and 13 women) were examined in this cross-sectional study. Selected adipokines, i.e. adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP-9), and allograft inflammatory factor-1 (AIF-1) with possible cardiovascular impact were measured in all participants. To identify markers of vascular damage von Willebrand factor (VWF), plasminogen activator inhibitor-1 (PAI-1) and arterial stiffness parameters were examined in all the subjects. Results: When compared with healthy controls, T2D had significantly higher levels of A-FABP 50.0 (38.1-68.6) vs. 28.6 (23.6-32.9) ng/mL, P below 0.0001 and lower levels of adiponectin 5.9 (4.3-9.0) vs. 11.3 (8.7-14.8) μg/mL, P below 0.000. Differences in other adipokines were not statistically significant. Adiponectin level correlated negatively with VWF levels (ρ =-0.29, P below 0.05) and PAI-1 (ρ =-0.36, P below 0.05) and A-FABP positively with VWF (ρ = 0.61, Pbelow 0.05) and PAI-1 (ρ = 0.47, P below 0.05) and augmentation index (ρ = 0.26, P below 0.05). Multivariate regression analysis showed independent association between A-FABP and VWF (b = 0.24, P below 0.05). Conclusions: Patients with T2D have significantly higher levels of A-FABP and lower levels of adiponectin. These adipokines correlate with indicators of vascular damage and could contribute to cardiovascular risk in patients with T2D. A-FABP may participate in direct endothelium damage.

Název v anglickém jazyce

Relationship of selected adipokines with markers of vascular damage in patients with type 2 diabetes

Popis výsledku anglicky

Background: In this study we compared levels of selected adipokines between patients with type 2 diabetes (T2D) and healthy individuals and we determined their relationship with early vascular damage markers. Methods: Seventy-seven subjects: 56 patients with T2D (34 men and 22 women) and 21 healthy controls (8 men and 13 women) were examined in this cross-sectional study. Selected adipokines, i.e. adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP-9), and allograft inflammatory factor-1 (AIF-1) with possible cardiovascular impact were measured in all participants. To identify markers of vascular damage von Willebrand factor (VWF), plasminogen activator inhibitor-1 (PAI-1) and arterial stiffness parameters were examined in all the subjects. Results: When compared with healthy controls, T2D had significantly higher levels of A-FABP 50.0 (38.1-68.6) vs. 28.6 (23.6-32.9) ng/mL, P below 0.0001 and lower levels of adiponectin 5.9 (4.3-9.0) vs. 11.3 (8.7-14.8) μg/mL, P below 0.000. Differences in other adipokines were not statistically significant. Adiponectin level correlated negatively with VWF levels (ρ =-0.29, P below 0.05) and PAI-1 (ρ =-0.36, P below 0.05) and A-FABP positively with VWF (ρ = 0.61, Pbelow 0.05) and PAI-1 (ρ = 0.47, P below 0.05) and augmentation index (ρ = 0.26, P below 0.05). Multivariate regression analysis showed independent association between A-FABP and VWF (b = 0.24, P below 0.05). Conclusions: Patients with T2D have significantly higher levels of A-FABP and lower levels of adiponectin. These adipokines correlate with indicators of vascular damage and could contribute to cardiovascular risk in patients with T2D. A-FABP may participate in direct endothelium damage.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Metabolic Syndrome and Related Disorders

ISSN

1540-4196

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

246-253

Kód UT WoS článku

000431268400001

EID výsledku v databázi Scopus

2-s2.0-85047940329