Mechanical thrombectomy in patients with acute ischemic stroke on anticoagulation therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000101" target="_blank" >RIV/00098892:_____/18:N0000101 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/18:73591721

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical thrombectomy in patients with acute ischemic stroke on anticoagulation therapy

Popis výsledku v původním jazyce

Mechanical thrombectomy (MT) for acute ischemic stroke (IS) can be performed also in patients on anticoagulation therapy (AT); however, sufficient and reliable data about safety and efficacy of MT are still missing. Thus, we aimed to compare these parameters between patients treated on AT and without AT. All consecutive IS patients treated with MT using stent retrievers were included in the retrospective analysis. Neurological deficit was scored using National Institutes of Health Stroke Scale (NIHSS) and 90-day clinical outcome using modified Rankin scale with a score 0-2 for good outcome. Recanalization was rated using Thrombolysis in Cerebral Infarction (TICI) scale. Symptomatic intracerebral hemorrhage (SICH) was assessed according to the SITS-MOST criteria. Out of 703 patients treated with MT, 88 (12.5 %) patients (46 % males, mean age 75.5 years) were on AT with an admission median NIHSS of 17 points. Recanalization (TICI 2b-3) was achieved in 80 % and complete (TICI 3) in 65 % of patients on AT and in 80 and 65 % of patients without AT (p-1.000). SICH after MT was detected in 9 % of AT and 5 % of non-AT patients (p-0.136). Good outcome was present in 36 % of AT patients (p-0.03). AT patients with poor outcome had more frequently atrial fibrillation (93 %, p-0.005), higher admission NIHSS (17, p-0.004) and higher rate of SICH (14.5 %, p-0.047). MT seems to be safe also in patients on AT. Poor outcome may be related to higher admission NIHSS, higher rate of SICH and presence of atrial fibrillation

Název v anglickém jazyce

Mechanical thrombectomy in patients with acute ischemic stroke on anticoagulation therapy

Popis výsledku anglicky

Mechanical thrombectomy (MT) for acute ischemic stroke (IS) can be performed also in patients on anticoagulation therapy (AT); however, sufficient and reliable data about safety and efficacy of MT are still missing. Thus, we aimed to compare these parameters between patients treated on AT and without AT. All consecutive IS patients treated with MT using stent retrievers were included in the retrospective analysis. Neurological deficit was scored using National Institutes of Health Stroke Scale (NIHSS) and 90-day clinical outcome using modified Rankin scale with a score 0-2 for good outcome. Recanalization was rated using Thrombolysis in Cerebral Infarction (TICI) scale. Symptomatic intracerebral hemorrhage (SICH) was assessed according to the SITS-MOST criteria. Out of 703 patients treated with MT, 88 (12.5 %) patients (46 % males, mean age 75.5 years) were on AT with an admission median NIHSS of 17 points. Recanalization (TICI 2b-3) was achieved in 80 % and complete (TICI 3) in 65 % of patients on AT and in 80 and 65 % of patients without AT (p-1.000). SICH after MT was detected in 9 % of AT and 5 % of non-AT patients (p-0.136). Good outcome was present in 36 % of AT patients (p-0.03). AT patients with poor outcome had more frequently atrial fibrillation (93 %, p-0.005), higher admission NIHSS (17, p-0.004) and higher rate of SICH (14.5 %, p-0.047). MT seems to be safe also in patients on AT. Poor outcome may be related to higher admission NIHSS, higher rate of SICH and presence of atrial fibrillation

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV17-30101A" target="_blank" >NV17-30101A: Rizikové faktory ischemické cévní mozkové příhody u mladých pacientů: vztah k epidemiologickým, sociálním, ekonomickým parametrům a životnímu stylu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cardiovascular and Interventional Radiology

ISSN

0174-1551

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

706-711

Kód UT WoS článku

000428802400006

EID výsledku v databázi Scopus

2-s2.0-85042081336