Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000127" target="_blank" >RIV/00098892:_____/18:N0000127 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00104656 RIV/61989592:15110/18:73592936

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0010865017300802?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010865017300802?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.crvasa.2017.04.003" target="_blank" >10.1016/j.crvasa.2017.04.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients.

Popis výsledku v původním jazyce

The aim of the prospective study was to evaluate the ability of echocardiography and cardiac biomarkers to predict in-hospital mortality and the risk of brain infarction during a 12-month follow-up period (FUP) with anticoagulation in pulmonary embolism (PE) patients. Methods: Eighty-eight consecutive acute PE patients (39 men, mean age 63 years) were enrolled; 78 underwent baseline echocardiography and brain magnetic resonance imaging (MRI). After a 12-month FUP, 58 underwent brain MRI. In-hospital mortality and the rates of new ischemic brain lesions (IBL) on MRI with clinical ischemic stroke (IS) events were predicted based on echocardiography. Results: Our series involved 88 patients, of whom 11 (12.5 %) presented high-risk PE, 24 (27.3 %) intermediate-high risk PE, 19 (21.6 %) intermediate-low risk PE and 34 (38.6 %) patients had low risk PE. Nine patients (10.2 %) died during hospitalization including high-risk PE 6/9 (66.6 %) and intermediate-high-risk PE 3/24 (12.5 %)]. cTnT (ODDS ratio - OR= 4.3; 95 % confidence interval 0.59–31.3, P = 0.014), NT-proBNP (OR 14.2 1.5–133.4, P = 0.02) were predictors of in-hospital mortality. Seventeen patients (19.3 %) experienced IS (n = 8) or new IBL (n = 9). Conclusions: High blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and ST were predictors of clinically apparent/silent brain infarction

Název v anglickém jazyce

Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients.

Popis výsledku anglicky

The aim of the prospective study was to evaluate the ability of echocardiography and cardiac biomarkers to predict in-hospital mortality and the risk of brain infarction during a 12-month follow-up period (FUP) with anticoagulation in pulmonary embolism (PE) patients. Methods: Eighty-eight consecutive acute PE patients (39 men, mean age 63 years) were enrolled; 78 underwent baseline echocardiography and brain magnetic resonance imaging (MRI). After a 12-month FUP, 58 underwent brain MRI. In-hospital mortality and the rates of new ischemic brain lesions (IBL) on MRI with clinical ischemic stroke (IS) events were predicted based on echocardiography. Results: Our series involved 88 patients, of whom 11 (12.5 %) presented high-risk PE, 24 (27.3 %) intermediate-high risk PE, 19 (21.6 %) intermediate-low risk PE and 34 (38.6 %) patients had low risk PE. Nine patients (10.2 %) died during hospitalization including high-risk PE 6/9 (66.6 %) and intermediate-high-risk PE 3/24 (12.5 %)]. cTnT (ODDS ratio - OR= 4.3; 95 % confidence interval 0.59–31.3, P = 0.014), NT-proBNP (OR 14.2 1.5–133.4, P = 0.02) were predictors of in-hospital mortality. Seventeen patients (19.3 %) experienced IS (n = 8) or new IBL (n = 9). Conclusions: High blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and ST were predictors of clinically apparent/silent brain infarction

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

1803-7712

Svazek periodika

60

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

e105-e113

Kód UT WoS článku

000429583200001

EID výsledku v databázi Scopus

2-s2.0-85019889981