Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000008" target="_blank" >RIV/00098892:_____/19:N0000008 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10402778 RIV/61989592:15110/19:73595569

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/68/68_921.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/68/68_921.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934141" target="_blank" >10.33549/physiolres.934141</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome

Popis výsledku v původním jazyce

The aim of the study was to investigate whether routine clinical parameters, including visceral adiposity index (VAI) and atherogenic index of plasma (AIP), could become widely applicable predictors of insulin resistance (IR), evaluated using homeostasis model assessment (HOMA-IR, HOMA-beta), with regard to presence of metabolic syndrome (MS). The study comprised 188 individuals identified to meet the MS criteria during regular health examinations and an equal number of age, sex-matched controls without MS. The strongest correlations were noted between HOMA-IR and waist circumference (WC) in the MS group (r=0.57) as well as between HOMA-IR and alanine aminotransferase (ALT, r=0.57) or aspartate aminotransferase (r=0.56) in the controls, with a statistical significance of p<0.001. In a multivariate linear regression model, the predictors of HOMA-IR were WC (linear coefficient beta=0.1, p<0.001), ALT (beta=2.28, p<0.001) and systolic blood pressure (beta=0.04, p<0.001). HOMA-beta was determined by WC (beta=1.97, p=0.032) and ALT (beta=99.49, p=0.004) and inversely associated with age (beta=-1.31, p=0.004). Neither VAI nor AIP were significant predictors. The presence of MS was significantly associated with both HOMA-IR and HOMA-beta. These results indicate that WC and ALT appear to be reliable predictors of IR. Comprehensive assessment of these parameters may serve for estimating the level of IR.

Název v anglickém jazyce

Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome

Popis výsledku anglicky

The aim of the study was to investigate whether routine clinical parameters, including visceral adiposity index (VAI) and atherogenic index of plasma (AIP), could become widely applicable predictors of insulin resistance (IR), evaluated using homeostasis model assessment (HOMA-IR, HOMA-beta), with regard to presence of metabolic syndrome (MS). The study comprised 188 individuals identified to meet the MS criteria during regular health examinations and an equal number of age, sex-matched controls without MS. The strongest correlations were noted between HOMA-IR and waist circumference (WC) in the MS group (r=0.57) as well as between HOMA-IR and alanine aminotransferase (ALT, r=0.57) or aspartate aminotransferase (r=0.56) in the controls, with a statistical significance of p<0.001. In a multivariate linear regression model, the predictors of HOMA-IR were WC (linear coefficient beta=0.1, p<0.001), ALT (beta=2.28, p<0.001) and systolic blood pressure (beta=0.04, p<0.001). HOMA-beta was determined by WC (beta=1.97, p=0.032) and ALT (beta=99.49, p=0.004) and inversely associated with age (beta=-1.31, p=0.004). Neither VAI nor AIP were significant predictors. The presence of MS was significantly associated with both HOMA-IR and HOMA-beta. These results indicate that WC and ALT appear to be reliable predictors of IR. Comprehensive assessment of these parameters may serve for estimating the level of IR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PHYSIOLOGICAL RESEARCH

ISSN

0862-8408

e-ISSN

1802-9973

Svazek periodika

68

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

921-930

Kód UT WoS článku

000505181300006

EID výsledku v databázi Scopus

2-s2.0-85077401942