Complex karyotype as a predictor of high-risk chronic lymphocytic leukemia: A single center experience over 12 years

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000047" target="_blank" >RIV/00098892:_____/19:N0000047 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/19:73595615 RIV/61989100:27240/19:10244308

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0145212619301638" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0145212619301638</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.leukres.2019.106218" target="_blank" >10.1016/j.leukres.2019.106218</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Complex karyotype as a predictor of high-risk chronic lymphocytic leukemia: A single center experience over 12 years

Popis výsledku v původním jazyce

Objectives: A complex karyotype (CK) is considered a poor prognostic marker in chronic lymphocytic leukemia (CLL). Methods: The study analyzed 644 untreated CLL patients (pts) using conventional/molecular cytogenetics to reveal the presence of a CK and its composition and to assess its predictive value. The mutational status ofTP53 was detected by next generation sequencing. Results: A CK was detected in 79 pts (12.3%). Patients with a CK showed shorter overall survival (OS) compared to those without a CK (77 months vs. 115 months, p < 0.0001). Chromosomes most frequently included in a CK were 13, 11, 17, 8, 2, and 6. The most common aberrations in a CK were translocations, numerical changes and dicentric chromosomes (with no effect on OS). Patients with aberrations ofTP53 and ATM were shown to have adverse prognosis comparable to patients with a CK without these abnormalities. A stronger impact of a CK on OS of female and older CLL patients was observed. Conclusions: The determining of the presence of a CK is essential in modern clinical CLL practice. According to recent studies, the presence of a CK affects clinical and treatment decision-making.

Název v anglickém jazyce

Complex karyotype as a predictor of high-risk chronic lymphocytic leukemia: A single center experience over 12 years

Popis výsledku anglicky

Objectives: A complex karyotype (CK) is considered a poor prognostic marker in chronic lymphocytic leukemia (CLL). Methods: The study analyzed 644 untreated CLL patients (pts) using conventional/molecular cytogenetics to reveal the presence of a CK and its composition and to assess its predictive value. The mutational status ofTP53 was detected by next generation sequencing. Results: A CK was detected in 79 pts (12.3%). Patients with a CK showed shorter overall survival (OS) compared to those without a CK (77 months vs. 115 months, p < 0.0001). Chromosomes most frequently included in a CK were 13, 11, 17, 8, 2, and 6. The most common aberrations in a CK were translocations, numerical changes and dicentric chromosomes (with no effect on OS). Patients with aberrations ofTP53 and ATM were shown to have adverse prognosis comparable to patients with a CK without these abnormalities. A stronger impact of a CK on OS of female and older CLL patients was observed. Conclusions: The determining of the presence of a CK is essential in modern clinical CLL practice. According to recent studies, the presence of a CK affects clinical and treatment decision-making.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

<a href="/cs/project/NV16-32339A" target="_blank" >NV16-32339A: Vliv funkčních polymorfismů ovlivňujících zánět a oxidační stres na průběh chronické lymfocytární leukémie a volbu individuální léčebné strategie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

LEUKEMIA RESEARCH

ISSN

0145-2126

e-ISSN

1873-5835

Svazek periodika

85

Číslo periodika v rámci svazku

October 2019

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

106218

Kód UT WoS článku

000489849900004

EID výsledku v databázi Scopus

2-s2.0-85071481687